PMID- 27790282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1738-3536 (Print)
IS  - 2005-6184 (Electronic)
IS  - 1738-3536 (Linking)
VI  - 79
IP  - 4
DP  - 2016 Oct
TI  - Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with 
      Airway Hyperresponsiveness in Asthma Patients.
PG  - 295-301
AB  - BACKGROUND: Specific immunoglobulin E (IgE) sensitization to staphylococcal 
      enterotoxin (SE) has been recently considered to be related to allergic disease, 
      including asthma. Despite studies on specific IgE (sIgE) to SE and its 
      relationship to asthma diagnosis and severity, the association of sIgE to SE with 
      airway hyperresponsiveness (AHR) remains unclear. METHODS: We enrolled 81 asthma 
      patients admitted to the Severance Hospital in Korea from March 1, 2013, to 
      February 28, 2015 and retrospectively reviewed the electronic medical records of 
      the enrolled subjects. The serum levels of sIgE to SE (A/B) of all subjects was 
      measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as 
      >0.10 kU/mL. RESULTS: The SE-sIgE level was not significantly correlated with 
      asthma severity (forced expiratory volume in 1 second [FEV(1)], FEV(1)/forced 
      vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE 
      level in patients with positive AHR (mean+/-standard error of the mean, 0.606+/-0.273 
      kU/mL) was significantly higher than that in patients with negative AHR 
      (0.062+/-0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to 
      SE >/=0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, 
      sex, FEV(1), and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 
      1.180-42.600; p=0.032). Prevalence of SE sensitization was higher in patients 
      with allergic rhinitis and non-atopic asthma patients, as compared to patients 
      without allergic rhinitis and atopic asthma patients, respectively, but without 
      statistical significance. CONCLUSION: SE sensitization is significantly 
      associated with AHR.
FAU - Kim, Seong Han
AU  - Kim SH
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Yang, Seo Yeon
AU  - Yang SY
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - You, Jihong
AU  - You J
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, Sang Bae
AU  - Lee SB
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - You, Jin
AU  - You J
AD  - Department of Internal Medicine, Kunkuk University School of Medicine, Seoul, 
      Korea.
FAU - Chang, Yoon Soo
AU  - Chang YS
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Kim, Hyung Jung
AU  - Kim HJ
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Ahn, Chul Min
AU  - Ahn CM
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Byun, Min Kwang
AU  - Byun MK
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Park, Hye Jung
AU  - Park HJ
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Park, Jung-Won
AU  - Park JW
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Severance 
      Hospital, Yonsei University College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20161005
PL  - Korea (South)
TA  - Tuberc Respir Dis (Seoul)
JT  - Tuberculosis and respiratory diseases
JID - 101479418
PMC - PMC5077734
OTO - NOTNLM
OT  - Asthma
OT  - Enterotoxins
OT  - Immunoglobulin E
OT  - Staphylococcus
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/10/30 06:00
MHDA- 2016/10/30 06:01
PMCR- 2016/10/01
CRDT- 2016/10/30 06:00
PHST- 2016/04/20 00:00 [received]
PHST- 2016/06/23 00:00 [revised]
PHST- 2016/08/09 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2016/10/30 06:01 [medline]
PHST- 2016/10/30 06:00 [entrez]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 10.4046/trd.2016.79.4.295 [doi]
PST - ppublish
SO  - Tuberc Respir Dis (Seoul). 2016 Oct;79(4):295-301. doi: 
      10.4046/trd.2016.79.4.295. Epub 2016 Oct 5.