PMID- 27790329
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1976-1902 (Print)
IS  - 1976-7846 (Electronic)
IS  - 1976-1902 (Linking)
VI  - 10
IP  - 5
DP  - 2016 Oct
TI  - Vitamin D Receptor Gene, Matrix Metalloproteinase 3 Polymorphisms and the Risk of 
      Intervertebral Disc Degeneration Susceptibility: Meta-Analysis.
PG  - 964-971
AB  - Several studies have evaluated the association between vitamin D receptor, matrix 
      metalloproteinase 3 (MMP-3) polymorphisms and the risk of intervertebral disc 
      degeneration susceptibility. The findings were inconsistent. This meta-analysis 
      aimed to systematically assess the association between vitamin D receptor, MMP-3 
      polymorphisms and the risk of intervertebral disc degeneration susceptibility. A 
      search of various databases was done covering all papers published until December 
      31th, 2014. Eight, 4, 3 studies were finally included that addressed the risk of 
      intervertebral disc degeneration susceptibility and vitamin D receptor FokI 
      (rs2228570), ApaI (rs7975232), and MMP-3 (rs731236) polymorphisms, respectively. 
      FokI (f vs. F: summary odds ratio [OR], 1.13; 95% confidence interval [CI], 
      0.76-1.69; ff vs. FF: OR, 1.02; 95% CI, 0.59-1.77; ff vs. Ff/FF: OR, 1.05; 95% 
      CI, 0.70-1.58), ApaI (a vs. A: OR, 0.73; 95% CI, 0.45-1.19; aa vs. AA: OR, 0.53; 
      95% CI, 0.22-1.25 p=0.14; aa vs. AA/Aa: OR, 0.69; 95% CI, 0.53-0.89) in the 
      vitamin D receptor gene and MMP3 polymorphisms (5A vs. 6A: OR, 1.92; 95% CI, 
      0.77-4.80; 5A5A vs. 6A6A: OR, 2.17; 95% CI, 0.75-6.24; 5A5A vs. 5A6A/6A6A: OR, 
      1.58; 95% CI, 0.72-3.44) were not obviously associated with risk of 
      intervertebral disc degeneration susceptibility. FokI, ApaI polymorphisms in the 
      vitamin D receptor gene and MMP-3 polymorphism are not obvious risk factors for 
      intervertebral disc degeneration susceptibility.
FAU - Nong, Luming
AU  - Nong L
AD  - Department of Orthopedics, Changzhou Second Hospital, Nanjing Medical University, 
      Changzhou, China.
FAU - Huang, Yongjing
AU  - Huang Y
AD  - Department of Orthopedics, Changzhou Second Hospital, Nanjing Medical University, 
      Changzhou, China.
FAU - Zhao, Shujie
AU  - Zhao S
AD  - Department of Orthopedics, Changzhou Second Hospital, Nanjing Medical University, 
      Changzhou, China.
FAU - Xu, Nanwei
AU  - Xu N
AD  - Department of Orthopedics, Changzhou Second Hospital, Nanjing Medical University, 
      Changzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161017
PL  - Korea (South)
TA  - Asian Spine J
JT  - Asian spine journal
JID - 101314177
PMC - PMC5081336
OTO - NOTNLM
OT  - Matrix metalloproteinase-3
OT  - Meta-analysis
OT  - Polymorphism
OT  - Vitamin D receptor
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/10/30 06:00
MHDA- 2016/10/30 06:01
PMCR- 2016/10/01
CRDT- 2016/10/30 06:00
PHST- 2015/11/23 00:00 [received]
PHST- 2016/01/16 00:00 [revised]
PHST- 2016/01/19 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2016/10/30 06:01 [medline]
PHST- 2016/10/30 06:00 [entrez]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 10.4184/asj.2016.10.5.964 [doi]
PST - ppublish
SO  - Asian Spine J. 2016 Oct;10(5):964-971. doi: 10.4184/asj.2016.10.5.964. Epub 2016 
      Oct 17.