PMID- 27791998
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20220409
IS  - 1875-8622 (Electronic)
IS  - 1386-0291 (Linking)
VI  - 64
IP  - 4
DP  - 2016
TI  - Interrelation of blood coagulation and hemorheology in cancer.
PG  - 635-644
LID - 10.3233/CH-168037 [doi]
AB  - Cancer progression is associated with activation of blood coagulation. Blood 
      coagulation process, platelet hemostasis and hemorheological properties were 
      evaluated in patients with solid tumors (n = 27) before and after surgery and in 
      healthy control (n = 20). The main features of blood coagulation process in 
      cancer patients were elevated intensity and shortened period of contact phase of 
      coagulation and inhibited fibrinolysis stage. Such prothrombotic state was fixed 
      before surgery as well as in early postoperative period in spite of preventing 
      thromboprophylactic treatment. Platelets depletion within the high level of 
      spontaneous and ADP-induced platelet aggregation was fixed in cancer. The main 
      cause of blood viscosity decrease in cancer patients was dramatic fall of Hct, 
      because blood viscosity adjusted by Hct 40% was increased owing to the rise of 
      plasma viscosity and substantially worsened RBC microrheological properties. The 
      results of our study indicated close correlation between hemorheological and 
      hemostasis parameters; these interrelations were more numerous and strong in 
      cancer. In cancer patients the combination of a high aggregation activity of 
      platelets, reduced number of erythrocytes (Hct), an increase of RBC aggregation 
      and plasma viscosity caused impairment of blood oxygen transportation efficacy 
      that provoke hypoxia in the microcirculation favoring thrombosis, settlement of 
      tumor and metastasis.
FAU - Tikhomirova, Irina
AU  - Tikhomirova I
AD  - Department of Medicine and Biology, Yaroslavl State Pedagogical University, 
      Yaroslavl, Russia.
FAU - Petrochenko, Elena
AU  - Petrochenko E
AD  - Department of Medicine and Biology, Yaroslavl State Pedagogical University, 
      Yaroslavl, Russia.
FAU - Malysheva, Yulia
AU  - Malysheva Y
AD  - Department of Medicine and Biology, Yaroslavl State Pedagogical University, 
      Yaroslavl, Russia.
FAU - Ryabov, Mihail
AU  - Ryabov M
AD  - Yaroslavl Regional Cancer Hospital, Yaroslavl, Russia.
FAU - Kislov, Nikolay
AU  - Kislov N
AD  - Yaroslavl Regional Cancer Hospital, Yaroslavl, Russia.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
SB  - IM
MH  - Aged
MH  - Blood Coagulation/*genetics
MH  - Disease Progression
MH  - Female
MH  - *Hemorheology
MH  - Hemostasis/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*blood
OTO - NOTNLM
OT  - Hemorheology
OT  - blood coagulation
OT  - cancer
OT  - platelet hemostasis
OT  - surgery
EDAT- 2016/10/30 06:00
MHDA- 2017/03/10 06:00
CRDT- 2016/10/30 06:00
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
AID - CH168037 [pii]
AID - 10.3233/CH-168037 [doi]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2016;64(4):635-644. doi: 10.3233/CH-168037.