PMID- 27793000
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20240324
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 48
DP  - 2016 Nov 29
TI  - DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell 
      carcinoma patient survival.
PG  - 79596-79604
LID - 10.18632/oncotarget.12865 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is one of the most common and aggressive 
      malignancies of the upper digestive tract. The present study is a retrospective 
      analysis of data from a prospective longitudinal study. A total of 170 male LSCC 
      patients (average age, 60.75+/-10.082) at the First Affiliated Hospital of Xi'an 
      Jiaotong University School of Medicine were recruited between January 2002 and 
      April 2013 for this study. We assessed correlations between patient 
      characteristics and survival, and sequenced genomic DNA from patient peripheral 
      blood samples. We found that the single nucleotide polymorphisms (SNPs), 
      rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were 
      associated with survival in LSCC patients. Median follow-up was 38 months (range 
      3-122) and median survival time was 48 months. LSCC patients with total 
      laryngectomy, poor differentiation, T3-T4 stage, N1-N2 stage or III-IV TNM stage 
      had reduced survival. This is the first study to demonstrate that the rs11903757 
      GT (HR=2.036; 95% CI, 1.071-3.872; p=0.030) and rs966423 TT (HR=11.677; 95% CI, 
      3.901-34.950; p=0.000) genotypes predict poor patient outcome. These 
      polymorphisms may serve as useful clinical markers to predict patient survival, 
      and to guide individual patient therapeutic decisions.
FAU - Shen, Zhen
AU  - Shen Z
AD  - Department of Otolaryngology & head neck, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
FAU - Ren, Wanli
AU  - Ren W
AD  - Department of Otolaryngology & head neck, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
FAU - Bai, Yanxia
AU  - Bai Y
AD  - Department of Otolaryngology & head neck, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
FAU - Chen, Zhengshuai
AU  - Chen Z
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
AD  - National Engineering Research Center for Miniaturized Detection Systems, Xi'an 
      710069, China.
FAU - Li, Jingjie
AU  - Li J
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
AD  - National Engineering Research Center for Miniaturized Detection Systems, Xi'an 
      710069, China.
FAU - Li, Bin
AU  - Li B
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
AD  - National Engineering Research Center for Miniaturized Detection Systems, Xi'an 
      710069, China.
FAU - Jin, Tianbo
AU  - Jin T
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
AD  - National Engineering Research Center for Miniaturized Detection Systems, Xi'an 
      710069, China.
FAU - Cao, Peilong
AU  - Cao P
AD  - Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China.
FAU - Shao, Yuan
AU  - Shao Y
AD  - Department of Otolaryngology & head neck, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Squamous Cell/*genetics/mortality/pathology/surgery
MH  - Cell Differentiation
MH  - Chi-Square Distribution
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Head and Neck Neoplasms/*genetics/mortality/pathology/surgery
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*genetics/mortality/pathology/surgery
MH  - Laryngectomy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC5346738
OTO - NOTNLM
OT  - DIRC3
OT  - NABP1
OT  - biomarker
OT  - laryngeal squamous cell carcinoma
OT  - polymorphism
COIS- CONFLICTS OF INTEREST The authors declare no conflicts of interest.
EDAT- 2016/10/30 06:00
MHDA- 2018/02/23 06:00
PMCR- 2016/11/29
CRDT- 2016/10/30 06:00
PHST- 2016/08/11 00:00 [received]
PHST- 2016/10/14 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
PHST- 2016/11/29 00:00 [pmc-release]
AID - 12865 [pii]
AID - 10.18632/oncotarget.12865 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Nov 29;7(48):79596-79604. doi: 10.18632/oncotarget.12865.