PMID- 27793545
OWN - NLM
STAT- MEDLINE
DCOM- 20180103
LR  - 20181113
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 56
DP  - 2016 Nov
TI  - Chronic binge alcohol consumption during pregnancy alters rat maternal uterine 
      artery pressure response.
PG  - 59-64
LID - S0741-8329(16)30175-6 [pii]
LID - 10.1016/j.alcohol.2016.10.005 [doi]
AB  - We aimed to investigate pressure-dependent maternal uterine artery responses and 
      vessel remodeling following gestational binge alcohol exposure. Two groups of 
      pregnant rats were used: the alcohol group (28.5% wt/v, 6.0 g/kg, once-daily 
      orogastric gavage in a binge paradigm between gestational day (GD) 5-19) and 
      pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary 
      uterine arteries were studied following equilibration (60 mm Hg) using dual 
      chamber arteriograph. The uterine artery diameter stabilized at 20 mm Hg, showed 
      passive distension at 40 mm Hg, and redeveloped tone at 60 mm Hg. An alcohol 
      effect (P = 0.0025) was observed on the percent constriction of vessel diameter 
      with greater pressure-dependent myogenic constriction. Similar alcohol effect was 
      noted with lumen diameter response (P = 0.0020). The percent change in 
      media:lumen ratio was higher in the alcohol group (P < 0.0001). Thus, gestational 
      alcohol affects pressure-induced uterine artery reactivity, inward-hypotrophic 
      remodeling, and adaptations critical for nutrient delivery to the fetus.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Naik, Vishal D
AU  - Naik VD
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
FAU - Lunde-Young, Emilie R
AU  - Lunde-Young ER
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
FAU - Davis-Anderson, Katie L
AU  - Davis-Anderson KL
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
FAU - Orzabal, Marcus
AU  - Orzabal M
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
FAU - Ivanov, Ivan
AU  - Ivanov I
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
FAU - Ramadoss, Jayanth
AU  - Ramadoss J
AD  - Department of Veterinary Physiology and Pharmacology, College of Veterinary 
      Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. 
      Electronic address: jramadoss@cvm.tamu.edu.
LA  - eng
GR  - K99 AA019446/AA/NIAAA NIH HHS/United States
GR  - R00 AA019446/AA/NIAAA NIH HHS/United States
GR  - R01 AA023520/AA/NIAAA NIH HHS/United States
GR  - R21 AA023035/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20161013
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Binge Drinking/complications/*physiopathology
MH  - Blood Pressure/*physiology
MH  - Ethanol/administration & dosage/*toxicity
MH  - Female
MH  - Organ Culture Techniques
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Uterine Artery/drug effects/*physiopathology
MH  - Vasoconstriction/drug effects/*physiology
PMC - PMC5296768
MID - NIHMS844982
OTO - NOTNLM
OT  - Alcohol
OT  - FASD
OT  - Pregnancy
OT  - Uterine
EDAT- 2016/10/30 06:00
MHDA- 2018/01/04 06:00
PMCR- 2017/11/01
CRDT- 2016/11/06 06:00
PHST- 2016/07/25 00:00 [received]
PHST- 2016/09/28 00:00 [revised]
PHST- 2016/10/04 00:00 [accepted]
PHST- 2016/11/06 06:00 [entrez]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2018/01/04 06:00 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - S0741-8329(16)30175-6 [pii]
AID - 10.1016/j.alcohol.2016.10.005 [doi]
PST - ppublish
SO  - Alcohol. 2016 Nov;56:59-64. doi: 10.1016/j.alcohol.2016.10.005. Epub 2016 Oct 13.