PMID- 2779356
OWN - NLM
STAT- MEDLINE
DCOM- 19891017
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 45
IP  - 8
DP  - 1989
TI  - Taste aversion involving central opioid antagonism is potentiated in 
      morphine-dependent rats.
PG  - 671-8
AB  - A sensitive taste conditioning test was used to measure the aversive effect of a 
      single intraventricular (i.c.v.) or subcutaneous (s.c) injection of an opioid 
      antagonist that readily crosses the blood brain barrier (naltrexone), and one of 
      two that do not (methylnaltrexone and diallylnormorphinium). This was done in 
      drug-naive rats and in rats implanted 5 days earlier with a pellet containing 75 
      mg morphine. It was found that the morphine exposure had no significant effect on 
      the dose-response curve of the taste aversion produced by s.c. methylnaltrexone 
      and s.c. diallynormorphinium but reduced the lowest effective dose for the other 
      antagonist treatments from three to more than 100 times. Consideration of the 
      data, together with the pharmacokinetic properties of the drugs and the routes of 
      administration used, supported a conclusion that only those aversions involving 
      central antagonist activity show the potentiation effect of chronic morphine 
      treatment. The findings were also discussed with regard to the location of 
      receptors important for aversions produced by opioid antagonists in naive rats.
FAU - Mucha, R F
AU  - Mucha RF
AD  - Addiction Research Foundation of Ontario, Toronto, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0RK7M7IABE (methylnaltrexone)
RN  - 5S6W795CQM (Naltrexone)
RN  - 69576-07-4 (diallylnormorphinium bromide)
RN  - U59WB2WRY2 (Nalorphine)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Infusions, Parenteral
MH  - Injections, Subcutaneous
MH  - Male
MH  - Morphine Dependence/*physiopathology
MH  - Nalorphine/administration & dosage/analogs & 
      derivatives/pharmacokinetics/pharmacology
MH  - Naltrexone/administration & dosage/analogs & 
      derivatives/pharmacokinetics/pharmacology
MH  - Narcotic Antagonists/administration & dosage/pharmacokinetics/*pharmacology
MH  - Quaternary Ammonium Compounds
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Taste/*drug effects
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 0024-3205(89)90084-2 [pii]
AID - 10.1016/0024-3205(89)90084-2 [doi]
PST - ppublish
SO  - Life Sci. 1989;45(8):671-8. doi: 10.1016/0024-3205(89)90084-2.