PMID- 27793717
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20170904
IS  - 1879-0720 (Electronic)
IS  - 0928-0987 (Linking)
VI  - 96
DP  - 2017 Jan 1
TI  - Synergistic role of solid lipid and porous silica in improving the oral delivery 
      of weakly basic poorly water soluble drugs.
PG  - 508-514
LID - S0928-0987(16)30465-1 [pii]
LID - 10.1016/j.ejps.2016.10.026 [doi]
AB  - Oral absorption of weakly basic drugs (e.g. cinnarizine (CIN)) is limited by 
      their pH dependent precipitation in intestinal conditions. To overcome this 
      challenge, a novel drug delivery system composed of solid lipid and porous 
      silica, namely silica encapsulated solid lipid (SESL) particles, was developed 
      via hot homogenization of melted lipid dispersion, followed by ultra-sonication 
      of the silica stabilized homogenized melted lipid dispersion. Scanning electron 
      microscope (SEM) images of the SESL formulation revealed non-spherical and 
      aggregated hybrid particles, with rough exterior and structured nanoparticles 
      visible on the surface. A 1.5, 2.2 and 7-fold improvement in the dissolution of 
      CIN was observed for the SESL particles, under simulated intestinal non-digesting 
      conditions, in comparison to the drug loaded in solid lipid (CIN-SL) matrix, drug 
      loaded in porous silica (CIN-PS) and pure drug powder. Under simulated intestinal 
      digestive condition, significant improvement in the drug solubilization was 
      reported for the SESL formulation in compared to the individual drug loaded 
      systems i.e. CIN-PS and CIN-SL. Thereby, silica encapsulated solid lipid system 
      provides a promising oral delivery approach for poorly water soluble weakly basic 
      drugs.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Yasmin, Rokhsana
AU  - Yasmin R
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia 5000, Australia.
FAU - Rao, Shasha
AU  - Rao S
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia 5000, Australia.
FAU - Bremmell, Kristen
AU  - Bremmell K
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia 5000, Australia.
FAU - Prestidge, Clive
AU  - Prestidge C
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia 5000, Australia. Electronic address: 
      Clive.Prestidge@unisa.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20161026
PL  - Netherlands
TA  - Eur J Pharm Sci
JT  - European journal of pharmaceutical sciences : official journal of the European 
      Federation for Pharmaceutical Sciences
JID - 9317982
RN  - 0 (Drug Carriers)
RN  - 0 (Lipids)
RN  - 059QF0KO0R (Water)
RN  - 3DI2E1X18L (Cinnarizine)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Administration, Oral
MH  - Cinnarizine/administration & dosage/*chemistry/pharmacokinetics
MH  - Drug Carriers/administration & dosage/*chemistry/pharmacokinetics
MH  - Drug Delivery Systems/*methods
MH  - Drug Synergism
MH  - Hydrogen-Ion Concentration
MH  - Lipids/administration & dosage/*chemistry/pharmacokinetics
MH  - Porosity
MH  - Silicon Dioxide/administration & dosage/*chemistry/pharmacokinetics
MH  - Solubility
MH  - Water/metabolism
OTO - NOTNLM
OT  - Oral delivery
OT  - Poorly water soluble drugs
OT  - Porous silica
OT  - Solid lipid
OT  - Solubilization
EDAT- 2016/10/30 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/10/30 06:00
PHST- 2016/08/24 00:00 [received]
PHST- 2016/10/20 00:00 [revised]
PHST- 2016/10/22 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
AID - S0928-0987(16)30465-1 [pii]
AID - 10.1016/j.ejps.2016.10.026 [doi]
PST - ppublish
SO  - Eur J Pharm Sci. 2017 Jan 1;96:508-514. doi: 10.1016/j.ejps.2016.10.026. Epub 
      2016 Oct 26.