PMID- 27795841
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2075-8251 (Print)
IS  - 2075-8251 (Linking)
VI  - 8
IP  - 3
DP  - 2016 Jul-Sep
TI  - Molecular and Cellular Mechanisms of Antitumor Immune Response Activation by 
      Dendritic Cells.
PG  - 17-30
AB  - Dendritic cells (DCs) play a crucial role in the initiation and regulation of the 
      antitumor immune response. Already , DC-based antitumor vaccines have been 
      thoroughly explored both in animal tumor models and in clinical trials. DC-based 
      vaccines are commonly produced from DC progenitors isolated from peripheral blood 
      or bone marrow by culturing in the presence of cytokines, followed by loading the 
      DCs with tumor-specific antigens, such as DNA, RNA, viral vectors, or a tumor 
      cell lysate. However, the efficacy of DC-based vaccines remains low. Undoubtedly, 
      a deeper understanding of the molecular mechanisms by which DCs function would 
      allow us to enhance the antitumor efficacy of DC-based vaccines in clinical 
      applications. This review describes the origin and major subsets of mouse and 
      human DCs, as well as the differences between them. The cellular mechanisms of 
      presentation and cross-presentation of exogenous antigens by DCs to T cells are 
      described. We discuss intracellular antigen processing in DCs, cross-dressing, 
      and the acquisition of the antigen cross-presentation function. A particular 
      section in the review describes the mechanisms of tumor escape from immune 
      surveillance through the suppression of DCs functions.
FAU - Markov, O V
AU  - Markov OV
AD  - Institute of Chemical Biology and Fundamental Medicine, Lavrentieva Ave., 8, 
      Novosibirsk, 630090 , Russia.
FAU - Mironova, N L
AU  - Mironova NL
AD  - Institute of Chemical Biology and Fundamental Medicine, Lavrentieva Ave., 8, 
      Novosibirsk, 630090 , Russia.
FAU - Vlasov, V V
AU  - Vlasov VV
AD  - Institute of Chemical Biology and Fundamental Medicine, Lavrentieva Ave., 8, 
      Novosibirsk, 630090 , Russia.
FAU - Zenkova, M A
AU  - Zenkova MA
AD  - Institute of Chemical Biology and Fundamental Medicine, Lavrentieva Ave., 8, 
      Novosibirsk, 630090 , Russia.
LA  - eng
PT  - Journal Article
PL  - Russia (Federation)
TA  - Acta Naturae
JT  - Acta naturae
JID - 101525823
PMC - PMC5081705
OTO - NOTNLM
OT  - antigen presentation and cross-presentation
OT  - dendritic cells
OT  - proteasome
OT  - subsets
OT  - tumor immunosuppression
EDAT- 2016/11/01 06:00
MHDA- 2016/11/01 06:01
PMCR- 2016/07/01
CRDT- 2016/11/01 06:00
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2016/11/01 06:01 [medline]
PHST- 2016/11/01 06:00 [entrez]
PHST- 2016/07/01 00:00 [pmc-release]
PST - ppublish
SO  - Acta Naturae. 2016 Jul-Sep;8(3):17-30.