PMID- 27796767
OWN - NLM
STAT- MEDLINE
DCOM- 20170710
LR  - 20181113
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 62
IP  - 1
DP  - 2017 Jan
TI  - Endoluminal Therapy for Gastroesophageal Reflux Disease: In Between the Pill and 
      the Knife?
PG  - 16-25
LID - 10.1007/s10620-016-4355-3 [doi]
AB  - Gastroesophageal reflux disease (GERD) is a chronic disease characterized by 
      symptoms of heartburn and acid regurgitation. Uncontrolled GERD can significantly 
      impact quality of life, can lead to complications, and increases the risk of 
      esophageal cancer. Over the past few decades, there has been an increasing 
      prevalence of GERD among adults in Western populations. The use of proton pump 
      inhibitors (PPI) in conjunction with lifestyle modifications remains the mainstay 
      therapy. However, the efficacy of this intervention is often hampered by 
      adherence, costs, and the risks of long-term PPI use. Anti-reflux surgery is an 
      option for patients with refractory symptoms or in those in whom medical therapy 
      is contraindicated or not desirable. While conventional surgery has an acceptable 
      safety profile, there has been an increasing interest in alternate treatments 
      that may potentially offer similar results and be associated with a faster 
      recovery. Recent advances in interventional endoluminal techniques have 
      introduced novel incisionless anti-reflux procedures. While the current data are 
      promising, further larger prospective studies are needed in order to assess the 
      long-term efficacy of endoluminal therapies and its place among the treatment 
      options for GERD.
FAU - Brar, Tony S
AU  - Brar TS
AD  - Department of Medicine, University of Florida, Gainesville, FL, USA.
FAU - Draganov, Peter V
AU  - Draganov PV
AD  - Division of Gastroenterology, Hepatology and Nutrition, University of Florida, 
      1329 SW 16th Street, Room #5251, Gainesville, FL, 32608, USA.
FAU - Yang, Dennis
AU  - Yang D
AD  - Division of Gastroenterology, Hepatology and Nutrition, University of Florida, 
      1329 SW 16th Street, Room #5251, Gainesville, FL, 32608, USA. 
      dennis.yang@medicine.ufl.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161028
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - *Catheter Ablation
MH  - Deglutition Disorders
MH  - Esophageal Sphincter, Lower/*surgery
MH  - *Esophagoscopy
MH  - Feeding Behavior
MH  - *Fundoplication
MH  - Gastroesophageal Reflux/*therapy
MH  - *Gastroscopy
MH  - Hernia, Hiatal
MH  - Histamine H2 Antagonists/therapeutic use
MH  - Humans
MH  - Injections
MH  - Laparoscopy
MH  - Magnets
MH  - Patient Compliance
MH  - Postoperative Complications
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Smoking Cessation
MH  - Weight Loss
OTO - NOTNLM
OT  - Endoluminal anterior fundoplication
OT  - Endoluminal therapy
OT  - Gastroesophageal reflux disease
OT  - Proton pump inhibitors
OT  - Radiofrequency ablation
OT  - Transoral incisionless fundoplication
EDAT- 2016/11/01 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/11/01 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
AID - 10.1007/s10620-016-4355-3 [pii]
AID - 10.1007/s10620-016-4355-3 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2017 Jan;62(1):16-25. doi: 10.1007/s10620-016-4355-3. Epub 2016 Oct 
      28.