PMID- 27796806
OWN - NLM
STAT- MEDLINE
DCOM- 20170317
LR  - 20181113
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Print)
IS  - 1058-0468 (Linking)
VI  - 34
IP  - 1
DP  - 2017 Jan
TI  - Correlation analysis between ultrasound findings and abnormal karyotypes in the 
      embryos from early pregnancy loss after in vitro fertilization-embryo transfer.
PG  - 43-50
LID - 10.1007/s10815-016-0821-2 [doi]
AB  - PURPOSE: The purpose of the study is to evaluate the correlation between 
      ultrasound findings and abnormal karyotypes in early pregnancy losses (EPLs) 
      after in vitro fertilization-embryo transfer (IVF-ET). METHODS: This 
      retrospective analysis assessed 2172 cases of EPL after IVF-ET occurring between 
      January 2008 and December 2013. The cases were examined via transvaginal 
      ultrasonography (TVS). Embryonic tissue karyotyping following miscarriage was 
      performed using a comparative genomic hybridization (CGH) analysis with 
      fluorescence in situ hybridization (FISH). The correlations between the 
      ultrasound findings and the karyotypes were evaluated. RESULTS: Six categories of 
      ultrasound findings were observed: normal ultrasound, empty sac, yolk sac only, 
      small gestational sac, small embryonic pole, and early symmetrical arrested 
      growth. The overall rate of abnormal karyotypes was 44.9 % (976/2172), and the 
      rate of abnormal karyotypes associated with a normal ultrasound, empty sac, yolk 
      sac only, small gestational sac, small embryonic pole, and early symmetrical 
      arrested growth was 49.5 % (218/440), 28.1 % (138/491), 43.4 % (197/454), 50.0 % 
      (43/86), 49.8 % (155/311), and 57.7 % (225/390), respectively. Compared with the 
      other groups, the prevalence of chromosomal abnormalities was significantly 
      higher in the early symmetrical arrested growth group but was markedly lower in 
      the empty sac group in all cases and when cases of 46,XX were excluded 
      (p < 0.05). Trisomy 16 was the most common chromosomal abnormality in the yolk 
      sac only, small embryonic pole and early symmetrical arrested growth groups. In 
      the empty sac, small gestational sac and normal ultrasound groups, monosomy X was 
      the most frequent abnormality. CONCLUSIONS: Chromosomal anomalies may be 
      associated with specific types of ultrasound findings in EPLs after IVF-ET.
FAU - Li, Xihong
AU  - Li X
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, No. 84, Xiangya road, 
      Changsha city, Hunan, 410078, China.
FAU - Ouyang, Yan
AU  - Ouyang Y
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, No. 84, Xiangya road, 
      Changsha city, Hunan, 410078, China.
AD  - Institute of Reproductive and Stem Cell Engineering, Central South University, 
      No. 84, Xiangya road, Changsha city, Hunan, 410078, China.
FAU - Yi, Yan
AU  - Yi Y
AD  - Institute of Reproductive and Stem Cell Engineering, Central South University, 
      No. 84, Xiangya road, Changsha city, Hunan, 410078, China.
FAU - Tan, Yueqiu
AU  - Tan Y
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, No. 84, Xiangya road, 
      Changsha city, Hunan, 410078, China. tanyueqiu@csu.edu.cn.
AD  - Institute of Reproductive and Stem Cell Engineering, Central South University, 
      No. 84, Xiangya road, Changsha city, Hunan, 410078, China. tanyueqiu@csu.edu.cn.
FAU - Lu, Guangxiu
AU  - Lu G
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, No. 84, Xiangya road, 
      Changsha city, Hunan, 410078, China. guangxiulu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20161028
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Abnormal Karyotype
MH  - Abortion, Spontaneous/diagnostic imaging/*genetics/pathology
MH  - Adult
MH  - Chromosome Aberrations
MH  - Comparative Genomic Hybridization
MH  - Embryo Transfer/*adverse effects
MH  - Female
MH  - Fertilization in Vitro/*adverse effects
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - *Ultrasonography, Prenatal
PMC - PMC5330976
OTO - NOTNLM
OT  - Early pregnancy loss
OT  - In vitro fertilization-embryo transfer
OT  - Karyotype
OT  - Transvaginal ultrasonography
OT  - Ultrasound findings
COIS- FUNDING: This study was supported by the National Natural Science (No. 81471432), 
      State Key Development Program for Basic Research of China (No.2012CB944901) and 
      the Scientific Research Foundation of Reproductive and Genetic Hospital of 
      Citic-Xiangya. CONFLICT OF INTEREST: The authors declare that they have no 
      conflict of interest.
EDAT- 2016/11/01 06:00
MHDA- 2017/03/18 06:00
PMCR- 2018/01/01
CRDT- 2016/11/01 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2016/09/22 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/03/18 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.1007/s10815-016-0821-2 [pii]
AID - 821 [pii]
AID - 10.1007/s10815-016-0821-2 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2017 Jan;34(1):43-50. doi: 10.1007/s10815-016-0821-2. Epub 
      2016 Oct 28.