PMID- 27796986
OWN - NLM
STAT- MEDLINE
DCOM- 20170413
LR  - 20181202
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 24
IP  - 2
DP  - 2017 Jan
TI  - Oxidized graphene-aggravated allergic asthma is antagonized by antioxidant 
      vitamin E in Balb/c mice.
PG  - 1784-1793
LID - 10.1007/s11356-016-7903-7 [doi]
AB  - Nanomaterials have been widely used in a number of applications; however, these 
      nanomaterials may potentially be risky for human health, particularly for the 
      respiratory system. In this study, we used a mouse asthma model to study whether 
      graphene oxide (GO), a promising carbonaceous nanomaterial with unique 
      physicochemical properties, aggravates allergic asthma via the oxidative stress 
      pathway. Mice were sensitized with ovalbumin (OVA) to trigger immune reactions, 
      while vitamin E (Ve) was administered as an antioxidant. Our results showed that 
      GO aggravated OVA-induced allergic asthma in mice, as suggested by increased 
      reactive oxygen species (ROS), elevated total immunoglobulin E (IgE), upregulated 
      Th2 response, and the aggravation of allergic asthma symptoms, such as airway 
      remolding, collagen deposition with mucus hypersecretion, and airway 
      hyperresponsiveness (AHR). The administration of Ve dramatically attenuated all 
      of the above effects. In conclusion, Ve showed anti-allergic properties in 
      antagonizing the exacerbation of allergic asthma induced by GO, providing a new 
      possibility for the treatment of allergic asthma.
FAU - Shang, Shuai
AU  - Shang S
AD  - Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic 
      Regulation and Integrative Biology, College of Life Science, Central China Normal 
      University, Wuhan, Hubei Province, 430079, China.
FAU - Li, Jinquan
AU  - Li J
AD  - Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic 
      Regulation and Integrative Biology, College of Life Science, Central China Normal 
      University, Wuhan, Hubei Province, 430079, China.
AD  - National Centre for International Research of Low-carbon and Green Buildings, 
      Chongqing University, Chongqing, 400045, People's Republic of China.
FAU - Zhao, Yun
AU  - Zhao Y
AD  - Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic 
      Regulation and Integrative Biology, College of Life Science, Central China Normal 
      University, Wuhan, Hubei Province, 430079, China.
FAU - Xi, Zhuge
AU  - Xi Z
AD  - Institute of Health and Environmental Medicine, Dali Road, Heping District, 
      Tianjin, 300050, People's Republic of China.
FAU - Lu, Zhisong
AU  - Lu Z
AD  - Institute for Clean Energy and Advanced Materials, Southwest University, 
      Chongqing, 400715, People's Republic of China.
FAU - Li, Baizhan
AU  - Li B
AD  - National Centre for International Research of Low-carbon and Green Buildings, 
      Chongqing University, Chongqing, 400045, People's Republic of China.
FAU - Yang, Xu
AU  - Yang X
AD  - Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic 
      Regulation and Integrative Biology, College of Life Science, Central China Normal 
      University, Wuhan, Hubei Province, 430079, China. yangxu@mail.ccnu.edu.cn.
FAU - Li, Rui
AU  - Li R
AD  - Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic 
      Regulation and Integrative Biology, College of Life Science, Central China Normal 
      University, Wuhan, Hubei Province, 430079, China. ruili@mail.ccnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20161029
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Antioxidants)
RN  - 1406-18-4 (Vitamin E)
RN  - 7782-42-5 (Graphite)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Antioxidants/*therapeutic use
MH  - Asthma/*etiology/prevention & control
MH  - Disease Models, Animal
MH  - Graphite/*adverse effects/*antagonists & inhibitors
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - Respiratory Hypersensitivity
MH  - Vitamin E/*therapeutic use
OTO - NOTNLM
OT  - Allergic asthma
OT  - Exacerbation effect
OT  - Graphene oxide
OT  - Oxidative stress
OT  - Vitamin E
EDAT- 2016/11/01 06:00
MHDA- 2017/04/14 06:00
CRDT- 2016/11/01 06:00
PHST- 2016/05/05 00:00 [received]
PHST- 2016/10/11 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/04/14 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
AID - 10.1007/s11356-016-7903-7 [pii]
AID - 10.1007/s11356-016-7903-7 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2017 Jan;24(2):1784-1793. doi: 
      10.1007/s11356-016-7903-7. Epub 2016 Oct 29.