PMID- 27797301
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20170328
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 129
IP  - 2
DP  - 2017 Mar
TI  - Relationship between lifestyle factors and hyperhomocysteinemia in general 
      Chinese population: a cross-sectional study.
PG  - 216-223
LID - 10.1080/00325481.2017.1255126 [doi]
AB  - OBJECTIVES: Hyperhomocysteinemia (Hhcy) is a known cardiovascular disease (CVD) 
      risk factor. Observational studies had supported the role of lifestyle factors 
      such as physical activity, diet and alcohol consumption in CVD prevention. Our 
      study aimed to determine the relationship between Hhcy and lifestyle factors in 
      general Chinese population. METHODS: In this cross-sectional study, a total of 
      7135 adults (3320 men and 3815 women) aged 35 years or older were recruited from 
      the rural Northeast China. Data on lifestyle factors, such as physical 
      activities, sleep duration, current smoking and drinking status, dietary habits 
      and familial factors were collected in interviews and laboratory examinations 
      were performed by well-trained personnel. RESULTS: Plasma total homocysteine 
      (tHcy) level was higher in men than in women, and greater in the elderly than in 
      other age groups. Subjects with Hhcy were more likely to be current smokers (men: 
      OR 1.328, 95% CI 1.143-1.543, p<0.001; women: OR 1.465, 95% CI 1.214-1.767, 
      p<0.001). Separately, men with Hhcy were more likely to have an education of 
      primary school or below (OR 1.251, 95% CI 1.068-1.465, p=0.006) and less likely 
      to eat more vegetables (OR 0.927, 95% CI 0.863-0.996, p=0.037) than the 
      normal-tHcy participants. In women, participants with Hhcy were more likely to 
      have longer sleeping time (>9h/d) (OR 1.677, 95% CI 1.292-2.177, p<0.001), low 
      physical activity (OR 1.721, 95% CI 1.197-2.475, p=0.044) and increased diet 
      score (OR 1.126, 95% CI 1.007-1.259, p=0.037) and less likely to be current 
      drinkers (OR 0.488, 95% CI 0.297-0.802, p=0.005) than the normal-tHcy 
      participants. CONCLUSION: Our study revealed that physical activity and current 
      drinking status were not significantly associated with Hhcy in males, but 
      inversely associated in females. In both genders, current smoking status and 
      dietary habits were significantly associated with Hhcy. Our study supports 
      existing recommendations for Chinese to maintain a physically active behaviors 
      and healthy lifestyle habits.
FAU - Chen, Shuang
AU  - Chen S
AD  - a Department of Cardiology , The First Affiliated Hospital of China Medical 
      University , Shenyang , P.R. China.
FAU - Guo, Xiaofan
AU  - Guo X
AD  - a Department of Cardiology , The First Affiliated Hospital of China Medical 
      University , Shenyang , P.R. China.
FAU - Dong, Siyuan
AU  - Dong S
AD  - b Department of Thoracic Surgery , The First Affiliated Hospital of China Medical 
      University , Shenyang , P.R. China.
FAU - Li, Zhao
AU  - Li Z
AD  - a Department of Cardiology , The First Affiliated Hospital of China Medical 
      University , Shenyang , P.R. China.
FAU - Sun, Yingxian
AU  - Sun Y
AD  - a Department of Cardiology , The First Affiliated Hospital of China Medical 
      University , Shenyang , P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20161118
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Alcohol Drinking/epidemiology
MH  - Blood Pressure
MH  - Body Weights and Measures
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diet
MH  - Exercise
MH  - Female
MH  - *Health Behavior
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*epidemiology
MH  - *Life Style
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sex Factors
MH  - Sleep
MH  - Smoking/epidemiology
MH  - Socioeconomic Factors
OTO - NOTNLM
OT  - Plasma homocysteine
OT  - epidemiology
OT  - hyperhomocysteinemia
OT  - lifestyle habits
OT  - physical activity
EDAT- 2016/11/01 06:00
MHDA- 2017/03/30 06:00
CRDT- 2016/11/01 06:00
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
AID - 10.1080/00325481.2017.1255126 [doi]
PST - ppublish
SO  - Postgrad Med. 2017 Mar;129(2):216-223. doi: 10.1080/00325481.2017.1255126. Epub 
      2016 Nov 18.