PMID- 27797716
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20170201
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 48
IP  - 12
DP  - 2016 Dec
TI  - Alteration of early dendritic cell activation by cancer cell lines predisposes 
      immunosuppression, which cannot be reversed by TLR4 stimulation.
PG  - 1101-1111
AB  - Dendritic cells (DCs) have shown promise for use in cancer vaccine and cancer 
      immunotherapy studies. However, we demonstrate that cancer cell lines can 
      negatively interfere with DC generation in granulocyte-macrophage 
      colony-stimulating factor (GM-CSF)-derived cultures, although cancer cells are 
      able to enhance CD80 cell surface activation marker and cytokine secretion. 
      Furthermore, in the presence of cancer cells, GM-CSF-derived DCs are unable to 
      stimulate T-cells. Additional stimulation with toll-like receptor 4 cannot fully 
      reverse the suppressive effect of cancer cells or supernatant. Hence, it is 
      imperative to understand the immunosuppressive effects of cancer on DCs in order 
      for DC-based cancer immunotherapy to be successful.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the 
      Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological 
      Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Kong, Ying Ying
AU  - Kong YY
AD  - Department of Immunology, Monash University AMREP Precinct, Melbourne, Victoria 
      3004, Australia.
FAU - Fuchsberger, Martina
AU  - Fuchsberger M
AD  - Department of Immunology, Monash University AMREP Precinct, Melbourne, Victoria 
      3004, Australia.
FAU - Plebanski, Magdalena
AU  - Plebanski M
AD  - Department of Immunology, Monash University AMREP Precinct, Melbourne, Victoria 
      3004, Australia Vasso.Apostolopoulos@vu.edu.au Magdalena.Plebanski@monash.edu.
FAU - Apostolopoulos, Vasso
AU  - Apostolopoulos V
AD  - Centre for Chronic Disease, College of Health and Biomedicine, Victoria 
      University, Melbourne, Victoria 3021, Australia Vasso.Apostolopoulos@vu.edu.au 
      Magdalena.Plebanski@monash.edu.
LA  - eng
PT  - Journal Article
DEP - 20161019
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Dendritic Cells/drug effects/*immunology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/metabolism
MH  - *Immune Tolerance
MH  - Immunotherapy
MH  - Lipopolysaccharides/administration & dosage
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Toll-Like Receptor 4/*agonists
OTO - NOTNLM
OT  - GM-CSF
OT  - cytokines
OT  - dendritic cells
OT  - early dendritic cells
EDAT- 2016/11/01 06:00
MHDA- 2017/02/02 06:00
CRDT- 2016/11/01 06:00
PHST- 2016/06/08 00:00 [received]
PHST- 2016/09/12 00:00 [revised]
PHST- 2016/08/19 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
AID - gmw102 [pii]
AID - 10.1093/abbs/gmw102 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1101-1111. doi: 
      10.1093/abbs/gmw102. Epub 2016 Oct 19.