PMID- 27798225
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20181113
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 43
IP  - 1
DP  - 2017 Jan
TI  - The Role of Cognition and Social Functioning as Predictors in the Transition to 
      Psychosis for Youth With Attenuated Psychotic Symptoms.
PG  - 57-63
LID - 10.1093/schbul/sbw152 [doi]
AB  - In the literature, there have been several attempts to develop prediction models 
      for youth who are at clinical high risk (CHR) of developing psychosis. Although 
      there are no specific clinical or demographic variables that seem to consistently 
      predict the later transition to psychosis in those CHR youth, in addition to 
      attenuated psychotic symptoms, the most commonly occuring predictors tend to be 
      poor social functioning and certain cognitive tasks. Unfortunately, there has 
      been little attempt to replicate alogorithms. A recently published article by 
      Cornblatt et al suggested that, for individuals with attentuated psychotic 
      symptoms (APS), disorganized communication, suspiciousness, verbal memory, and a 
      decline in social functioning were the best predictors of later transition to 
      psychosis (the RAP model). The purpose of this article was to first test the 
      prediction model of Cornblatt et al with a new sample of individuals with APS 
      from the PREDICT study. The RAP model was not the best fit for the PREDICT data. 
      However, using other variables from PREDICT, it was demonstrated that unusual 
      thought content, disorganized communication, baseline social functioning, verbal 
      fluency, and memory, processing speed and age were predictors of later transition 
      to psychosis in the PREDICT sample. Although the predictors were different in 
      these 2 models, both supported that disorganized communication, poor social 
      functioning, and verbal memory, were good candidates as predictors for later 
      conversion to psychosis.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the Maryland 
      Psychiatric Research Center. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, AB, Canada; jmadding@ucalgary.ca.
FAU - Liu, Lu
AU  - Liu L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, AB, Canada.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC.
FAU - Carrion, Ricardo E
AU  - Carrion RE
AD  - Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY.
FAU - Keefe, Richard S E
AU  - Keefe RS
AD  - Department of Psychiatry, Duke University, Durham, NC.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT.
LA  - eng
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20161025
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cognitive Dysfunction/*diagnosis/etiology
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Models, Statistical
MH  - *Prodromal Symptoms
MH  - Prognosis
MH  - Psychotic Disorders/complications/*diagnosis
MH  - Risk
MH  - Schizophrenia/*diagnosis
MH  - *Social Behavior
MH  - Young Adult
PMC - PMC5216866
OTO - NOTNLM
OT  - clinical high risk
OT  - prediction
OT  - prodromal
OT  - schizophrenia
EDAT- 2016/11/01 06:00
MHDA- 2017/07/25 06:00
PMCR- 2018/01/01
CRDT- 2016/11/01 06:00
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - sbw152 [pii]
AID - 10.1093/schbul/sbw152 [doi]
PST - ppublish
SO  - Schizophr Bull. 2017 Jan;43(1):57-63. doi: 10.1093/schbul/sbw152. Epub 2016 Oct 
      25.