PMID- 27799316
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20180125
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 103
IP  - 9
DP  - 2017 May
TI  - Longitudinal strain combined with delayed-enhancement magnetic resonance improves 
      risk stratification in patients with dilated cardiomyopathy.
PG  - 679-686
LID - 10.1136/heartjnl-2016-309746 [doi]
AB  - OBJECTIVE: Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) 
      imaging has been reported to be associated with unfavourable outcomes; however, 
      few studies have addressed the prognostic value of left ventricular (LV) 
      deformation parameter indicated by global longitudinal strain (GLS) in 
      two-dimensional speckle-tracking (2DST) echocardiography in patients with 
      non-ischaemic dilated cardiomyopathy (DCM). This study aims to investigate 
      whether the combination of GLS and LGE is useful in stratifying the risk in 
      patients with DCM. METHODS: We studied 179 consecutive symptomatic patients with 
      DCM (age, 61+/-15 years; 121 males; left ventricular ejection fraction (LVEF) 
      33%+/-9%; New York Heart Association (NYHA) class II: n=71, III: n=107, IV: n=1) 
      who underwent CMR and echocardiography with conventional assessment and 2DST 
      analysis. RESULTS: There were 40 rehospitalisations for heart failure, including 
      7 cardiac deaths and 2 implantations of LV assist device during follow-up 
      (3.8+/-2.5 years). Univariable Cox proportional hazard regression analysis showed 
      that NYHA class, blood pressure, B-type natriuretic peptide, LV end-diastolic and 
      end-systolic volumes, LVEF, left atrium volume, GLS and LGE were significantly 
      associated with long-term outcome. Multivariable analysis revealed that GLS and 
      LGE were independently associated with long-term outcome (p<0.05, both). In 
      additional analyses, we found independent associations between GLS and LV reverse 
      remodelling after the optimal medical therapy, and between LGE and 
      life-threatening arrhythmias (p<0.05, both). CONCLUSION: Combining GLS and LGE 
      could be useful for risk stratification and prognostic assessment in patients 
      with DCM.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Chimura, Misato
AU  - Chimura M
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Onishi, Tetsuari
AU  - Onishi T
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Tsukishiro, Yasue
AU  - Tsukishiro Y
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Sawada, Takahiro
AU  - Sawada T
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Kiuchi, Kunihiko
AU  - Kiuchi K
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Shimane, Akira
AU  - Shimane A
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Okajima, Katsunori
AU  - Okajima K
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Yamada, Shinichiro
AU  - Yamada S
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Taniguchi, Yasuyo
AU  - Taniguchi Y
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Yasaka, Yoshinori
AU  - Yasaka Y
AD  - Himeji Cardiovascular Center, Himeji, Japan.
FAU - Kawai, Hiroya
AU  - Kawai H
AD  - Himeji Cardiovascular Center, Himeji, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161031
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Biomechanical Phenomena
MH  - Cardiomyopathy, Dilated/*diagnostic imaging/mortality/physiopathology/therapy
MH  - Chi-Square Distribution
MH  - Contrast Media/*administration & dosage
MH  - Disease-Free Survival
MH  - *Echocardiography, Doppler, Color
MH  - Female
MH  - Gadolinium DTPA/*administration & dosage
MH  - Heart Failure/mortality/physiopathology/therapy
MH  - Heart-Assist Devices
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Longitudinal Studies
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Myocardial Contraction
MH  - Observer Variation
MH  - Patient Readmission
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stress, Mechanical
MH  - Stroke Volume
MH  - *Ventricular Function, Left
MH  - Ventricular Remodeling
EDAT- 2016/11/02 06:00
MHDA- 2017/07/25 06:00
CRDT- 2016/11/02 06:00
PHST- 2016/04/03 00:00 [received]
PHST- 2016/10/04 00:00 [revised]
PHST- 2016/10/05 00:00 [accepted]
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
AID - heartjnl-2016-309746 [pii]
AID - 10.1136/heartjnl-2016-309746 [doi]
PST - ppublish
SO  - Heart. 2017 May;103(9):679-686. doi: 10.1136/heartjnl-2016-309746. Epub 2016 Oct 
      31.