PMID- 27799569
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20190320
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 58
IP  - 7
DP  - 2017 Jul
TI  - Tris-acryl gelatin microspheres versus gelatin sponge particles in uterine artery 
      embolization for leiomyoma.
PG  - 834-841
LID - 10.1177/0284185116674499 [doi]
AB  - Background Tris-acryl gelatin microspheres (TAGM) and gelatin sponge particles 
      (GS) have been used in uterine artery embolization (UAE) for leiomyoma. No direct 
      comparisons of both embolic agents have been reported. Purpose To compare the 
      outcomes of UAE with TAGM with those of UAE with GS for uterine leiomyoma. 
      Material and Methods This was a non-randomized, single-institute, non-inferiority 
      study. Between July 2008 and August 2015, 67 consecutive patients with 
      symptomatic leiomyoma underwent UAE. GS was used for the first 49 patients and 
      TAGM was used for the following 18 patients. The primary endpoint was tumor 
      infarction on contrast-enhanced magnetic resonance imaging (MRI) 1 week after 
      UAE. The secondary endpoints were changes in symptoms and quality-of-life scores 
      with UFS-QOL questionnaires at 4 months, and adverse events (AEs) in the 4 months 
      after UAE. Results The baseline characteristics of both groups were similar. 
      Complete or nearly complete tumor infarction (>/=90%) was achieved in 94.4% (17/18) 
      of the TAGM group and 93.6% (44/47) of the GS group. This difference (0.8%; 95% 
      CI, -11.9% to 13.5%) indicated the non-inferiority of the TAGM group to the GS 
      group, with a pre-specified non-inferiority margin of 20%. No significant 
      differences were observed in improvements in symptoms or quality-of-life scores 
      at 4 months ( P = 0.56 and P = 0.19) or in 4-month AEs ( P = 0.29). Conclusion 
      The outcomes of UAE with TAGM were comparable to those of UAE with GS, suggesting 
      that both embolic agents are acceptable for the treatment of leiomyoma.
FAU - Katsumori, Tetsuya
AU  - Katsumori T
AD  - 1 Department of Radiology, Saiseikai Shiga Hospital, Shiga, Japan.
FAU - Miura, Hiroshi
AU  - Miura H
AD  - 1 Department of Radiology, Saiseikai Shiga Hospital, Shiga, Japan.
FAU - Arima, Hisatomi
AU  - Arima H
AD  - 2 Department of Preventive Medicine and Public Health Faculty of Medicine, 
      Fukuoka University, Fukuoka, Japan.
FAU - Hino, Akihiko
AU  - Hino A
AD  - 3 Department of Neurosurgery, Saiseikai Shiga Hospital, Shiga, Japan.
FAU - Tsuji, Yusuke
AU  - Tsuji Y
AD  - 1 Department of Radiology, Saiseikai Shiga Hospital, Shiga, Japan.
FAU - Masuda, Yoko
AU  - Masuda Y
AD  - 1 Department of Radiology, Saiseikai Shiga Hospital, Shiga, Japan.
FAU - Nishimura, Takeshi
AU  - Nishimura T
AD  - 1 Department of Radiology, Saiseikai Shiga Hospital, Shiga, Japan.
LA  - eng
PT  - Clinical Study
PT  - Comparative Study
PT  - Journal Article
DEP - 20161031
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 0 (Acrylic Resins)
RN  - 0 (Hemostatics)
RN  - 0 (trisacryl gelatin microspheres)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - *Acrylic Resins
MH  - Adult
MH  - Female
MH  - *Gelatin
MH  - *Gelatin Sponge, Absorbable
MH  - *Hemostatics
MH  - Humans
MH  - Leiomyoma/*therapy
MH  - Non-Randomized Controlled Trials as Topic
MH  - Treatment Outcome
MH  - Uterine Artery Embolization/*methods
MH  - Uterine Neoplasms/*therapy
OTO - NOTNLM
OT  - Uterine artery embolization
OT  - fibroid
OT  - gelatin sponge
OT  - leiomyoma
OT  - magnetic resonance imaging (MRI)
OT  - tris-acryl gelatin microspheres
EDAT- 2016/11/02 06:00
MHDA- 2019/03/21 06:00
CRDT- 2016/11/02 06:00
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
AID - 0284185116674499 [pii]
AID - 10.1177/0284185116674499 [doi]
PST - ppublish
SO  - Acta Radiol. 2017 Jul;58(7):834-841. doi: 10.1177/0284185116674499. Epub 2016 Oct 
      31.