PMID- 27800196
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2016
DP  - 2016
TI  - Chronic Disseminated Candidiasis Complicated by Immune Reconstitution 
      Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia.
PG  - 5960150
LID - 5960150
AB  - Hepatosplenic candidiasis also known as chronic disseminated candidiasis is a 
      rare manifestation of invasive fungal infection typically observed in patients 
      with acute leukemia in prolonged, deep neutropenia. Immune reconstitution 
      inflammatory syndrome (IRIS) is an inflammatory disorder triggered by rapid 
      resolution of neutropenia. Diagnosis and treatment of IRIS are still challenging 
      due to a variety of clinical symptoms, lack of certain diagnostic criteria, and 
      no standards of treatment. The diagnosis of IRIS is even more difficult in 
      patients with hematological malignancies complicated by "probable" invasive 
      fungal infection, when fungal pathogen is still uncertain. We report a case of 
      probable hepatic candidiasis in 4-year-old boy with acute lymphoblastic leukemia. 
      Despite proper antifungal therapy, there was no clinical and radiological 
      improvement, so diagnosis of Candida-related IRIS was made and corticosteroid 
      therapy was added to antifungal treatment achieving prompt resolution of 
      infection symptoms.
FAU - Zajac-Spychala, Olga
AU  - Zajac-Spychala O
AUID- ORCID: 0000-0002-8836-8605
AD  - Department of Pediatric Oncology, Hematology and Transplantology, University of 
      Medical Sciences, Poznan, Poland.
FAU - Ukielska, Bogna
AU  - Ukielska B
AD  - Department of Pediatric Oncology, Hematology and Transplantology, University of 
      Medical Sciences, Poznan, Poland.
FAU - Jonczyk-Potoczna, Katarzyna
AU  - Jonczyk-Potoczna K
AD  - Department of Pediatric Radiology, University of Medical Sciences, Poznan, 
      Poland.
FAU - Konatkowska, Benigna
AU  - Konatkowska B
AD  - Department of Pediatric Oncology, Hematology and Transplantology, University of 
      Medical Sciences, Poznan, Poland.
FAU - Wachowiak, Jacek
AU  - Wachowiak J
AD  - Department of Pediatric Oncology, Hematology and Transplantology, University of 
      Medical Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
DEP - 20161009
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC5075288
EDAT- 2016/11/02 06:00
MHDA- 2016/11/02 06:01
PMCR- 2016/10/09
CRDT- 2016/11/02 06:00
PHST- 2016/07/21 00:00 [received]
PHST- 2016/09/18 00:00 [accepted]
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2016/11/02 06:01 [medline]
PHST- 2016/11/02 06:00 [entrez]
PHST- 2016/10/09 00:00 [pmc-release]
AID - 10.1155/2016/5960150 [doi]
PST - ppublish
SO  - Case Rep Hematol. 2016;2016:5960150. doi: 10.1155/2016/5960150. Epub 2016 Oct 9.