PMID- 27801341
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20181202
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 55
IP  - 11
DP  - 2016 Nov 1
TI  - [The expression of p27(Kip1) and beta-catenin in multiple endocrine neoplasia type 
      1-related parathyroid tumors].
PG  - 859-862
LID - 10.3760/cma.j.issn.0578-1426.2016.11.009 [doi]
AB  - Objective: To explore tissue expression of cyclin-dependent kinase inhibitor 
      p27(Kip1) and beta-catenin in multiple endocrine neoplasia type1 (MEN1)-related 
      parathyroid tumors (MHPT). Methods: Immunohistochemistry was performed to analyze 
      the expression of p27(Kip1) and beta-catenin in parathyroid glands from 31 subjects 
      with MHPT collected at Peking Union Medical College Hospital from 2002 to 2013. 
      Five normal parathyroid glands were used as control. Results: In MHPT subjects, 
      nuclear expression of p27(Kip1) was absent in 4 (12.9%), weak in 10 (32.3%) and 
      moderated staining in 17 parathyroid specimens (54.8%), respectively. While, in 
      normal subjects, the nuclear expression of p27(Kip1) was observed in all subjects 
      and was stronger than that from MHPT subjects (P=0.001). As to the expression of 
      beta-catenin, normal parathyroid showed a distinct to moderate membrane staining, a 
      moderate to weak cytoplasmic staining and negative nuclear staining. Similarly, 
      MHPT exhibited a marked to moderate membrane (P=0.087), a moderated to weak 
      cytoplasmic (P=0.357), and negative nuclear beta-catenin staining. Conclusions: The 
      expression of p27(Kip1) is reduced or absent in MHPT tissue, and no nuclear 
      expression of beta-catenin is observed in the tumors, which suggesting p27(Kip1,) 
      but not beta-catenin nuclear accumulation, play a role in the development of the 
      tumors.
FAU - Kong, J
AU  - Kong J
AD  - Department of Endocrinology, Key Laboratory of Endocrinology, National Health and 
      Family Planning Commission, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
FAU - Wang, O
AU  - Wang O
FAU - Nie, M
AU  - Nie M
FAU - Shi, J
AU  - Shi J
FAU - Jiang, Y
AU  - Jiang Y
FAU - Li, M
AU  - Li M
FAU - Xia, W B
AU  - Xia WB
FAU - Meng, X W
AU  - Meng XW
FAU - Xing, X P
AU  - Xing XP
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (beta Catenin)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Cyclin-Dependent Kinase Inhibitor p27/*genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Parathyroid Neoplasms/*genetics/pathology
MH  - beta Catenin/*genetics
EDAT- 2016/11/02 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/11/02 06:00
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
AID - 10.3760/cma.j.issn.0578-1426.2016.11.009 [doi]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2016 Nov 1;55(11):859-862. doi: 
      10.3760/cma.j.issn.0578-1426.2016.11.009.