PMID- 27801414
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20181023
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 88
IP  - 10
DP  - 2016
TI  - [Incretin secretion and glucose metabolism in morbidly obese patients in the 
      early and late periods after biliopancreatic diversion].
PG  - 9-18
LID - 10.17116/terarkh201688109-18 [doi]
AB  - AIM: To estimate the parameters of glucose metabolism and to assess the secretion 
      of incretins in patients after biliopancreatic diversion (BPD) for morbid obesity 
      (MO) in the early and late postoperative periods. SUBJECTS AND METHODS: The 
      prospective part of the investigation included 22 patients with a body mass index 
      of 35.8 to 68.4 kg/m2 and type 2 diabetes mellitus (T2DM). All the patients were 
      examined before, 3 weeks and 3 months after BPD. The retrospective part covered 
      23 patients who were examined after BPD for MO; the postoperative period was 4.7 
      [2.3; 7.2] years. A control group consisted of 22 healthy, normal weight 
      volunteers. A 75-g oral glucose tolerance test was carried out in all the groups 
      to study the levels of glucose, immunoreactive insulin (IRI), glucagon-like 
      peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and 
      glucagon at 0, 30, 60, and 120 min. RESULTS: T2DM patients showed improvement in 
      glucose metabolism just 3 weeks after BPD; following 3 months, they had 
      normalized fasting blood glucose levels (5.6 [5.0; 6.0] mmol/l). During 3 months, 
      glycated hemoglobin decreased from 7.5 [6.6; 8.5] to 5.7 [5.3; 5.9]%. In the 
      early period following BPD, there was an increase in basal and postprandial GLP-1 
      levels associated with the peak IRI concentration. In the late period after BPD, 
      the enhanced secretion of IRI and GLP-1 persisted, which was followed by a 
      reduction in postprandial glucose levels in 4 of the 23 patients. CONCLUSION: 
      T2DM remission does not depend on weight loss in the early period after BPD. In 
      this period, the significant improvement of glucose metabolic parameters in 
      patients with obesity and T2DM is associated with elevated GLP-1 levels. The 
      altered incretin response is a stable effect of BPD and remains in its late 
      period.
FAU - Dedov, I I
AU  - Dedov II
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia; M.V. 
      Lomonosov Moscow State University, Moscow, Russia.
FAU - Melnichenko, G A
AU  - Melnichenko GA
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Troshina, E A
AU  - Troshina EA
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Ershova, E V
AU  - Ershova EV
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Mazurina, N V
AU  - Mazurina NV
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Ogneva, N A
AU  - Ogneva NA
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Yashkov, Yu I
AU  - Yashkov YI
AD  - Center for Endosurgery and Lithotripsy, Moscow, Russia.
FAU - Ilyin, capital A, Cyrillic V
AU  - Ilyin capital A, CyrillicV
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Produktsiya inkretinov i obmen glyukozy u bol'nykh patologicheskim ozhireniem v 
      rannem i otdalennom periode posle biliopankreaticheskogo shuntirovaniya.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Incretins)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Biliopancreatic Diversion/adverse effects/methods
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/blood/complications/therapy
MH  - Female
MH  - *Glucagon-Like Peptide 1/analysis/blood
MH  - *Glucose/analysis/metabolism
MH  - Humans
MH  - *Incretins/analysis/metabolism
MH  - Male
MH  - *Obesity, Morbid/complications/diagnosis/metabolism/surgery
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Russia
MH  - Statistics as Topic
EDAT- 2016/11/02 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/11/02 06:00
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
AID - 10.17116/terarkh201688109-18 [doi]
PST - ppublish
SO  - Ter Arkh. 2016;88(10):9-18. doi: 10.17116/terarkh201688109-18.