PMID- 27801417
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20181023
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 88
IP  - 10
DP  - 2016
TI  - [Acute-phase serum proteins and adipocytokines in women with type 2 diabetes 
      mellitus: Relationships with body composition and blood glucose fluctuations].
PG  - 35-41
LID - 10.17116/terarkh2016881035-41 [doi]
AB  - AIM: To estimate the relationships between the serum concentrations of 
      acute-phase proteins (APPs) and adipocytokines, body composition (BC), and blood 
      glucose (BG) fluctuations in women with type 2 diabetes mellitus (T2DM). SUBJECTS 
      AND METHODS: A total of 165 women with T2DM and 22 with a normal body mass index 
      (BMI) at the age of 40 to 70 years were examined. The concentrations of 
      high-sensitivity C-reactive protein (hs-CRP) and acid alpha1-glycoprotein (alpha1-AGP) 
      were determined by ELISA. The levels of interleukins 6, 8, and 18 (IL-6, IL-8, 
      IL-18), tumor necrosis factor-alpha (TNF-alpha), and plasminogen activator inhibitor type 
      1 (PAI-1) were measured by a multiplex analysis. Dual energy X-ray absorptiometry 
      was used to estimate BC parameters. BG fluctuations were estimated via continuous 
      glucose monitoring. RESULTS: The levels of hs-CRP, alpha1-AGP, IL-6, IL-8, IL-18, 
      TNF-alpha, and PAI-1 were significantly higher in the obese women with T2DM than 
      those in the control group. In the diabetic normal weight women, only hs-CRP, 
      alpha1-AGP, and IL-8 concentrations exceeded those in the controls. The level of 
      hs-CRP (other than alpha1-AGP) correlated positively with BMI, the mass of adipose 
      tissue, body trunk (android), and gynoid fats. A multivariate regression analysis 
      showed that adipose tissue mass and trunk fat proportion were independent 
      predictors of hs-CRP levels. The concentrations of IL-6, IL-8, IL-18, PAI-1, and 
      TNF-alpha correlated positively with waist-to-hip ratio, but demonstrated no 
      associations with BMI and BC. Only the serum alpha1-AGP level showed a positive 
      association with mean BG and its variability parameters. CONCLUSION: In the women 
      with T2DM, the serum concentrations of APPs and adipocytokines correlate 
      differently with the mass of adipose tissue, its distribution, and BG 
      fluctuations. The findings indicate the multifactorial genesis of chronic 
      inflammation in these patients.
FAU - Klimontov, V V
AU  - Klimontov VV
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Tyan, N V
AU  - Tyan NV
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Fazullina, O N
AU  - Fazullina ON
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Myakina, N E
AU  - Myakina NE
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Orlov, N B
AU  - Orlov NB
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Konenkov, V I
AU  - Konenkov VI
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
LA  - rus
PT  - Journal Article
TT  - Belki ostroi fazy vospaleniya i adipotsitokiny v syvorotke krovi u zhenshchin s 
      sakharnym diabetom 2-go tipa: vzaimosvyazi s sostavom tela i kolebaniyami urovnya 
      glyukozy v krovi.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Absorptiometry, Photon/methods
MH  - *Acute-Phase Proteins/analysis/metabolism
MH  - Adipokines/*blood
MH  - *Blood Glucose/analysis/metabolism
MH  - *Body Composition
MH  - C-Reactive Protein
MH  - Diabetes Mellitus, Type 2/complications/diagnosis/metabolism
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Obesity/blood/complications/diagnosis
MH  - Statistics as Topic
EDAT- 2016/11/02 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/11/02 06:00
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
AID - 10.17116/terarkh2016881035-41 [doi]
PST - ppublish
SO  - Ter Arkh. 2016;88(10):35-41. doi: 10.17116/terarkh2016881035-41.