PMID- 27802435
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20181202
IS  - 1421-9824 (Electronic)
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 42
IP  - 5-6
DP  - 2016
TI  - Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: 
      The HAPIEE Study.
PG  - 297-309
AB  - BACKGROUND/AIMS: Oxidative stress is involved in Alzheimer disease pathology, but 
      its impact on cognitive function in community-dwelling older adults remains 
      unknown. We estimated associations between serum oxidative stress markers and 
      cognitive function in early old age. METHODS: Subjects aged 45-69 years recruited 
      in urban centers in Central and Eastern Europe had memory, verbal fluency, and 
      processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives 
      of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), 
      and total thiol levels (TTLs) were measured at baseline in a subsample. Linear 
      regression was used to estimate associations of biomarkers with cognitive test 
      scores cross-sectionally (n = 4,304) and prospectively (n = 2,882). RESULTS: 
      Increased d-ROM levels were inversely associated with global cognition and verbal 
      fluency cross-sectionally and in prospective analysis; observed effects 
      corresponded to 3-4 years' higher age. TTL was inconsistently associated with 
      memory. BAP was not related to cognitive function. CONCLUSION: This study found 
      modest evidence for a relationship between serum d-ROMs and cognitive function in 
      a population sample of older adults.
CI  - (c) 2016 The Author(s) Published by S. Karger AG, Basel.
FAU - Horvat, Pia
AU  - Horvat P
AD  - Department of Epidemiology and Public Health, University College London, London, 
      UK.
FAU - Kubinova, Ruzena
AU  - Kubinova R
FAU - Pajak, Andrzej
AU  - Pajak A
FAU - Tamosiunas, Abdonas
AU  - Tamosiunas A
FAU - Schottker, Ben
AU  - Schottker B
FAU - Pikhart, Hynek
AU  - Pikhart H
FAU - Peasey, Anne
AU  - Peasey A
FAU - Kozela, Magdalena
AU  - Kozela M
FAU - Jansen, Eugene
AU  - Jansen E
FAU - Singh-Manoux, Archana
AU  - Singh-Manoux A
FAU - Bobak, Martin
AU  - Bobak M
LA  - eng
GR  - R01 AG023522/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20161102
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Sulfhydryl Compounds)
SB  - IM
MH  - Aged
MH  - Antioxidants/*metabolism
MH  - Biomarkers/blood
MH  - *Cognition
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - *Memory
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - *Oxidative Stress
MH  - Prospective Studies
MH  - Reactive Oxygen Species/*blood
MH  - Sulfhydryl Compounds/*blood
PMC - PMC5121567
EDAT- 2016/11/02 06:00
MHDA- 2018/01/24 06:00
PMCR- 2016/11/02
CRDT- 2016/11/02 06:00
PHST- 2016/09/09 00:00 [accepted]
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
PHST- 2016/11/02 00:00 [pmc-release]
AID - 000450702 [pii]
AID - dem-0042-0297 [pii]
AID - 10.1159/000450702 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2016;42(5-6):297-309. doi: 10.1159/000450702. Epub 
      2016 Nov 2.