PMID- 27802518
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 14
DP  - 2016 Nov 1
TI  - Diagnostic Performance of Peripapillary Retinal Nerve Fiber Layer Thickness for 
      Detection of Glaucoma in an Elderly Population: The ALIENOR Study.
PG  - 5882-5891
LID - 10.1167/iovs.16-20104 [doi]
AB  - PURPOSE: To assess diagnostic accuracy of spectral-domain optical coherence 
      tomography (SD-OCT) to discriminate glaucoma and control subjects in an elderly 
      population. METHODS: The antioxidants, essential lipids, nutrition and ocular 
      maladies study (ALIENOR: "Antioxydants, Lipides Essentiels, Nutrition et Maladies 
      Oculaires") is a population-based study. From 2009 to 2010, a total of 624 
      subjects, aged 74 years or older underwent a complete eye examination, including 
      optic disc color photography and SD-OCT examination of the macula and the optic 
      nerve head. Glaucoma diagnosis was made using retinophotography of the optic 
      nerve head and International Society for Epidemiologic and Geographical 
      Ophthalmology criteria. Average and sectorial peripapillary retinal nerve fiber 
      layer thicknesses (RNFLT) were compared between glaucoma and control subjects 
      using area under the receiver operating characteristic curves (AUC), positive and 
      negative likelihood ratios (LR+/LR-), and diagnostic odds ratios (DOR). RESULTS: 
      A total of 532 subjects had complete data, 492 were classified as controls and 40 
      were classified as glaucoma. Mean age was 82.1 +/- 4.2 years and average RNFLT was 
      significantly different between both groups (controls: 88.7 +/- 12.2 mum, glaucoma: 
      65.4 +/- 14.4 mum, P < 0.001). Highest AUC values were observed for average (0.895), 
      temporal-inferior (0.874), and temporal-superior (0.868) RNFLT. Temporal-superior 
      RNFLT had the highest DOR (25.31; LR+, 4.65; LR-, 0.18), followed by average 
      RNFLT (DOR: 24.80; LR+, 6.36; LR-, 0.26). When using the normative database 
      provided by the machine, DOR increased to 31.03 (LR+, 1.75; LR-, 0.06) if at 
      least one parameter was considered abnormal (at P < 0.05). CONCLUSIONS: 
      Parameters of SD-OCT RNFL may provide valuable information in a screening 
      strategy to improve glaucoma detection in a general population of elderly people.
FAU - Schweitzer, Cedric
AU  - Schweitzer C
AD  - CHU Bordeaux, Department of Ophthalmology, Bordeaux, France 2Universite de 
      Bordeaux, ISPED, Bordeaux, France 3INSERM, U1219 - Bordeaux Population Health 
      Research Center, Bordeaux, France.
FAU - Korobelnik, Jean-Francois
AU  - Korobelnik JF
AD  - CHU Bordeaux, Department of Ophthalmology, Bordeaux, France 2Universite de 
      Bordeaux, ISPED, Bordeaux, France 3INSERM, U1219 - Bordeaux Population Health 
      Research Center, Bordeaux, France.
FAU - Le Goff, Melanie
AU  - Le Goff M
AD  - Universite de Bordeaux, ISPED, Bordeaux, France 3INSERM, U1219 - Bordeaux 
      Population Health Research Center, Bordeaux, France.
FAU - Rahimian, Olivier
AU  - Rahimian O
AD  - CHU Bordeaux, Department of Ophthalmology, Bordeaux, France 2Universite de 
      Bordeaux, ISPED, Bordeaux, France.
FAU - Malet, Florence
AU  - Malet F
AD  - CHU Bordeaux, Department of Ophthalmology, Bordeaux, France.
FAU - Rougier, Marie-Benedicte
AU  - Rougier MB
AD  - CHU Bordeaux, Department of Ophthalmology, Bordeaux, France.
FAU - Delyfer, Marie-Noelle
AU  - Delyfer MN
AD  - CHU Bordeaux, Department of Ophthalmology, Bordeaux, France 2Universite de 
      Bordeaux, ISPED, Bordeaux, France 3INSERM, U1219 - Bordeaux Population Health 
      Research Center, Bordeaux, France.
FAU - Dartigues, Jean-Francois
AU  - Dartigues JF
AD  - Universite de Bordeaux, ISPED, Bordeaux, France 3INSERM, U1219 - Bordeaux 
      Population Health Research Center, Bordeaux, France.
FAU - Delcourt, Cecile
AU  - Delcourt C
AD  - Universite de Bordeaux, ISPED, Bordeaux, France 3INSERM, U1219 - Bordeaux 
      Population Health Research Center, Bordeaux, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/pathology
MH  - Optic Nerve Diseases/*pathology
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2016/11/02 06:00
MHDA- 2017/06/07 06:00
CRDT- 2016/11/02 06:00
PHST- 2016/11/02 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2016/11/02 06:00 [entrez]
AID - 2579548 [pii]
AID - 10.1167/iovs.16-20104 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):5882-5891. doi: 
      10.1167/iovs.16-20104.