PMID- 27804054
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20170206
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 31
IP  - 2
DP  - 2017 Feb
TI  - Regional myocardial damage and active inflammation in patients with cardiac 
      sarcoidosis detected by non-invasive multi-modal imaging.
PG  - 135-143
LID - 10.1007/s12149-016-1136-1 [doi]
AB  - AIMS: Cardiac sarcoidosis (CS) can be diagnosed using (18)F-FDG-PET/CT (PET), 
      cardiovascular magnetic resonance (CMR), and (123)I-BMIPP/(201)TlCl dual 
      myocardial SPECT. This study aims to clarify the relationships among the three 
      modalities with respect to CS. METHODS AND RESULTS: We evaluated 16 patients 
      (male n = 11; age 55 +/- 13 years) with confirmed CS who underwent PET, CMR, and 
      dual SPECT with gated SPECT before starting steroid therapy. The left ventricular 
      myocardium was divided into 17 segments to obtain SUVmax for PET images, defect 
      scores from 0 to 4 (0 normal; 4 absent), and mismatch scores for dual SPECT 
      (BMDS, TLDS, and MS) images and late gadolinium enhancement (LGE) scores (0 none; 
      1 partly positive; 2 homogeneous) on CMR images. Summed BMDS, TLDS, and MS were 
      18.6 +/- 12.6, 12.9 +/- 10.9, and 5.7 +/- 3.1, respectively. The segmental BMDS and 
      TLDS scores became significantly higher as the LGE scores increased. The MS 
      scores were significantly higher in areas of LGE with a score of 1 than 0 (both, 
      p < 0.001), but did not significantly differ between areas with LGE scores of 1 
      and 2. The SUVmax was significantly higher in LGE areas with a score of 1 than 0 
      (p < 0.025), but did not significantly differ between those with scores of 1 or 
      2. CONCLUSION: Regions with a higher SUVmax indicating active myocardial 
      inflammation were mainly located in areas with LGE, where BMIPP and TL mismatches 
      were evident in patients with CS.
FAU - Kataoka, Shohei
AU  - Kataoka S
AD  - Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Momose, Mitsuru
AU  - Momose M
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. momose.mitsuru@twmu.ac.jp.
FAU - Fukushima, Kenji
AU  - Fukushima K
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Serizawa, Naoki
AU  - Serizawa N
AD  - Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Suzuki, Atsushi
AU  - Suzuki A
AD  - Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Kondo, Chisato
AU  - Kondo C
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Abe, Koichiro
AU  - Abe K
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Sakai, Shuji
AU  - Sakai S
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Hagiwara, Nobuhisa
AU  - Hagiwara N
AD  - Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161101
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Contrast Media)
RN  - 0 (Fatty Acids)
RN  - 0 (Iodobenzenes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0J7USQ749M (iodofiltic acid)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathies/*diagnostic imaging/immunology
MH  - Contrast Media
MH  - Fatty Acids
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Gadolinium
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Iodobenzenes
MH  - *Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - *Multimodal Imaging/methods
MH  - Myocarditis/*diagnostic imaging
MH  - Myocardium/immunology/pathology
MH  - Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Sarcoidosis/*diagnostic imaging/immunology
MH  - *Tomography, Emission-Computed, Single-Photon/methods
MH  - *Tomography, X-Ray Computed/methods
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Cardiac sarcoidosis
OT  - Fatty acid metabolism
OT  - Myocardial perfusion
OT  - Positron emission tomography
EDAT- 2016/11/03 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/11/03 06:00
PHST- 2016/05/11 00:00 [received]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/11/03 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
PHST- 2016/11/03 06:00 [entrez]
AID - 10.1007/s12149-016-1136-1 [pii]
AID - 10.1007/s12149-016-1136-1 [doi]
PST - ppublish
SO  - Ann Nucl Med. 2017 Feb;31(2):135-143. doi: 10.1007/s12149-016-1136-1. Epub 2016 
      Nov 1.