PMID- 27805038
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Nov 2
TI  - Interactive effect of serum uric acid and total bilirubin for cardiovascular 
      disease in Chinese patients with type 2 diabetes.
PG  - 36437
LID - 10.1038/srep36437 [doi]
LID - 36437
AB  - Serum uric acid (SUA) at high levels and bilirubin at low levels were potent 
      antioxidant but it was uncertain that whether SUA and total bilirubin (TBIL) had 
      additive interaction for the risk of CVD in type 2 diabetes mellitus (T2DM). We 
      conducted a cross-sectional survey of 6713 inpatients with T2DM and admitted to 
      81 tertiary care hospitals. CVD was defined as having either prior coronary heart 
      disease or stroke or peripheral arterial disease. Binary logistic regression was 
      used to estimate odds ratios of SUA and TBIL for CVD. The effect size of additive 
      interaction was estimated by three measures, i.e., relative excess risk due to 
      interaction, attributable proportion due to interaction and synergy index. Among 
      6713 patients with T2DM, 561 (8.36%) suffered from CVD. Using >/=283 umol/L 
      (median) to define high SUA and <11.5 umol/L (n = 2290 or 34.11%) to define low 
      TBIL, copresence of both factors (n = 621 or 9.25%) was associated with 5.18-fold 
      (95% CI, 4.00-6.72) risk of CVD with significant additive interactions in 
      multivariable analysis as compared to absence of both risk factors. The 
      copresence of both high SUA and low TBIL was associated with a large increased 
      risk of CVD in high-risk Chinese patients with type 2 diabetes.
FAU - Ren, Yanfeng
AU  - Ren Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Department of Health Statistics, School of Public Health and Management, Weifang 
      Medical University, Shandong, China.
FAU - Jin, Nan
AU  - Jin N
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
FAU - Hong, Tianpei
AU  - Hong T
AD  - Department of Endocrinology, Peking University Third Hospital, Beijing, China.
FAU - Mu, Yiming
AU  - Mu Y
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Lixin
AU  - Guo L
AD  - Department of Endocrinology, Beijing Hospital, Beijing, China.
FAU - Ji, Qiuhe
AU  - Ji Q
AD  - Department of Endocrinology, The Fourth Military Medical University Xi Jing 
      Hospital, Xi'an, China.
FAU - Li, Qiang
AU  - Li Q
AD  - Department of Endocrinology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang, China.
FAU - Yang, Xilin
AU  - Yang X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161102
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 268B43MJ25 (Uric Acid)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Bilirubin/blood
MH  - Cardiovascular Diseases/complications/*diagnosis
MH  - China
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*diagnosis
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Risk Factors
MH  - Stroke/complications/diagnosis
MH  - Uric Acid/blood
PMC - PMC5090353
EDAT- 2016/11/03 06:00
MHDA- 2018/05/15 06:00
PMCR- 2016/11/02
CRDT- 2016/11/03 06:00
PHST- 2016/05/17 00:00 [received]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2016/11/03 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2016/11/03 06:00 [entrez]
PHST- 2016/11/02 00:00 [pmc-release]
AID - srep36437 [pii]
AID - 10.1038/srep36437 [doi]
PST - epublish
SO  - Sci Rep. 2016 Nov 2;6:36437. doi: 10.1038/srep36437.