PMID- 27805623
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20180720
IS  - 1559-064X (Electronic)
IS  - 1559-0631 (Linking)
VI  - 27
IP  - 6
DP  - 2017 Nov
TI  - Dermal absorption of benzo[a]pyrene into human skin from soil: Effect of 
      artificial weathering, concentration, and exposure duration.
PG  - 610-617
LID - 10.1038/jes.2016.61 [doi]
AB  - In vitro assessments of (14)C-benzo[a]pyrene (BaP) absorption through human 
      epidermis were conducted with the sub-63-mum fraction of four test soils 
      containing different amounts of organic and black carbon. Soils were artificially 
      weathered for eight weeks and applied to epidermis at nominal BaP concentrations 
      of 3 and 10 mg/kg for 8 or 24 h. Experiments were also conducted at 24 h with 
      unweathered soils and with BaP deposited onto skin from acetone at a comparable 
      chemical load. For the weathered soils, absorption was independent of the amount 
      of organic or black carbon, the mass in the receptor fluid was proportional to 
      exposure duration but independent of concentration, and the mass recovered in the 
      skin after washing was proportional to concentration and independent of exposure 
      time. Results from the weathered and unweathered soils were similar except for 
      the mass recovered in the washed skin, which was lower for the weathered soil 
      only at the higher concentration. We hypothesize that chemical concentrations 
      exceeded the BaP sorption capacity accessible within the artificial weathering 
      timeframe for all soils tested, and that BaP mass in the washed skin was 
      dominated by particles that were not removed by washing. Fluxes into and through 
      skin from soils were lower by an order of magnitude than from acetone-deposited 
      BaP.
FAU - Peckham, Trevor K
AU  - Peckham TK
AD  - Department of Environmental and Occupational Health Services, School of Public 
      Health, University of Washington, Seattle, WA, USA.
FAU - Shirai, Jeffry H
AU  - Shirai JH
AD  - Department of Environmental and Occupational Health Services, School of Public 
      Health, University of Washington, Seattle, WA, USA.
FAU - Bunge, Annette L
AU  - Bunge AL
AD  - Chemical and Biological Engineering Department, Colorado School of Mines, Golden, 
      CO, USA.
FAU - Lowney, Yvette W
AU  - Lowney YW
AD  - Exponent, Boulder, CO, USA.
FAU - Ruby, Michael V
AU  - Ruby MV
AD  - Integral Consulting, Louisville, CO, USA.
FAU - Kissel, John C
AU  - Kissel JC
AD  - Department of Environmental and Occupational Health Services, School of Public 
      Health, University of Washington, Seattle, WA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161102
PL  - United States
TA  - J Expo Sci Environ Epidemiol
JT  - Journal of exposure science & environmental epidemiology
JID - 101262796
RN  - 0 (Soil Pollutants)
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Benzo(a)pyrene/*analysis/*metabolism
MH  - Cells, Cultured/metabolism
MH  - Environmental Exposure/*analysis
MH  - Environmental Monitoring/methods
MH  - Humans
MH  - Skin/*metabolism
MH  - *Skin Absorption
MH  - Soil Pollutants/*analysis/*metabolism
EDAT- 2016/11/03 06:00
MHDA- 2018/02/06 06:00
CRDT- 2016/11/03 06:00
PHST- 2016/02/26 00:00 [received]
PHST- 2016/07/01 00:00 [revised]
PHST- 2016/07/05 00:00 [accepted]
PHST- 2016/11/03 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2016/11/03 06:00 [entrez]
AID - jes201661 [pii]
AID - 10.1038/jes.2016.61 [doi]
PST - ppublish
SO  - J Expo Sci Environ Epidemiol. 2017 Nov;27(6):610-617. doi: 10.1038/jes.2016.61. 
      Epub 2016 Nov 2.