PMID- 27807606 OWN - NLM STAT- MEDLINE DCOM- 20171205 LR - 20190318 IS - 1432-2072 (Electronic) IS - 0033-3158 (Linking) VI - 234 IP - 2 DP - 2017 Jan TI - BDNF concentrations and daily fluctuations differ among ADHD children and respond differently to methylphenidate with no relationship with depressive symptomatology. PG - 267-279 LID - 10.1007/s00213-016-4460-1 [doi] AB - RATIONALE: Brain-derived neurotrophic factor (BDNF) enhances the growth and maintenance of several monoamine neuronal systems, serves as a neurotransmitter modulator and participates in the mechanisms of neuronal plasticity. Therefore, BDNF is a good candidate for interventions in the pathogenesis and/or treatment response of attention deficit hyperactivity disorder (ADHD). OBJECTIVE: We quantified the basal concentration and daily fluctuation of serum BDNF, as well as changes after methylphenidate treatment. METHOD: A total of 148 children, 4-5 years old, were classified into groups as follows: ADHD group (n = 107, DSM-IV-TR criteria) and a control group (CG, n = 41). Blood samples were drawn at 2000 and 0900 hours from both groups, and after 4.63 +/- 2.3 months of treatment, blood was drawn only from the ADHD group for BDNF measurements. Factorial analysis was performed (Stata software, version 12.0). RESULTS: Morning BDNF (36.36 +/- 11.62 ng/ml) in the CG was very similar to that in the predominantly inattentive children (PAD), although the evening concentration in the CG was higher (CG 31.78 +/- 11.92 vs PAD 26.41 +/- 11.55 ng/ml). The hyperactive-impulsive group, including patients with comorbid conduct disorder (PHI/CD), had lower concentrations. Methylphenidate (MPH) did not modify the concentration or the absence of daily BDNF fluctuations in the PHI/CD children; however, MPH induced a significant decrease in BDNF in PAD and basal day/night fluctuations disappeared in this ADHD subtype. This profile was not altered by the presence of depressive symptoms. CONCLUSIONS: Our data support a reduction in BDNF in untreated ADHD due to the lower concentrations in PHI/CD children, which is similar to other psychopathologic and cognitive disorders. MPH decreased BDNF only in the PAD group, which might indicate that BDNF is not directly implicated in the methylphenidate-induced amelioration of the neuropsychological and organic immaturity of ADHD patients. FAU - Cubero-Millan, Isabel AU - Cubero-Millan I AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. FAU - Ruiz-Ramos, Maria-Jose AU - Ruiz-Ramos MJ AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. FAU - Molina-Carballo, Antonio AU - Molina-Carballo A AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. amolinac@ugr.es. AD - Servicio de Neuropediatria, Neuropsicologia y Atencion Temprana, Unidad de Gestion Clinica de Pediatria, Complejo Hospitalario Granada, Hospital Clinico San Cecilio, Avda Dr. Oloriz 16, Granada, Spain. amolinac@ugr.es. FAU - Martinez-Serrano, Sylvia AU - Martinez-Serrano S AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. FAU - Fernandez-Lopez, Luisa AU - Fernandez-Lopez L AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. FAU - Machado-Casas, Irene AU - Machado-Casas I AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. AD - Servicio de Neuropediatria, Neuropsicologia y Atencion Temprana, Unidad de Gestion Clinica de Pediatria, Complejo Hospitalario Granada, Hospital Clinico San Cecilio, Avda Dr. Oloriz 16, Granada, Spain. FAU - Tortosa-Pinto, Pilar AU - Tortosa-Pinto P AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. FAU - Ruiz-Lopez, Aida AU - Ruiz-Lopez A AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. FAU - Luna-Del-Castillo, Juan-de-Dios AU - Luna-Del-Castillo JD AD - Departamento de BioEstadistica, Facultad de Medicina, Universidad de Granada, Granada, Spain. FAU - Uberos, Jose AU - Uberos J AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. AD - Servicio de Neuropediatria, Neuropsicologia y Atencion Temprana, Unidad de Gestion Clinica de Pediatria, Complejo Hospitalario Granada, Hospital Clinico San Cecilio, Avda Dr. Oloriz 16, Granada, Spain. FAU - Munoz-Hoyos, Antonio AU - Munoz-Hoyos A AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Granada, Avda de Madrid 12, 18012, Granada, Spain. amunozh@ugr.es. AD - Servicio de Neuropediatria, Neuropsicologia y Atencion Temprana, Unidad de Gestion Clinica de Pediatria, Complejo Hospitalario Granada, Hospital Clinico San Cecilio, Avda Dr. Oloriz 16, Granada, Spain. amunozh@ugr.es. LA - eng PT - Journal Article DEP - 20161103 PL - Germany TA - Psychopharmacology (Berl) JT - Psychopharmacology JID - 7608025 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Central Nervous System Stimulants) RN - 207ZZ9QZ49 (Methylphenidate) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adolescent MH - Attention Deficit Disorder with Hyperactivity/*blood/*drug therapy/psychology MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Central Nervous System Stimulants/pharmacology/therapeutic use MH - Child MH - Child, Preschool MH - Depression/*blood/*drug therapy/psychology MH - Female MH - Humans MH - Impulsive Behavior/drug effects/physiology MH - Male MH - Methylphenidate/pharmacology/*therapeutic use MH - Prospective Studies MH - Treatment Outcome OTO - NOTNLM OT - *ADHD OT - *ADHD subgroups OT - *BDNF OT - *Children OT - *Comorbidities OT - *Daily rhythms OT - *Depressive symptoms OT - *Human OT - *Methylphenidate OT - *Serum EDAT- 2016/11/04 06:00 MHDA- 2017/12/06 06:00 CRDT- 2016/11/04 06:00 PHST- 2016/04/16 00:00 [received] PHST- 2016/10/06 00:00 [accepted] PHST- 2016/11/04 06:00 [pubmed] PHST- 2017/12/06 06:00 [medline] PHST- 2016/11/04 06:00 [entrez] AID - 10.1007/s00213-016-4460-1 [pii] AID - 10.1007/s00213-016-4460-1 [doi] PST - ppublish SO - Psychopharmacology (Berl). 2017 Jan;234(2):267-279. doi: 10.1007/s00213-016-4460-1. Epub 2016 Nov 3.