PMID- 27811505
OWN - NLM
STAT- MEDLINE
DCOM- 20190116
LR  - 20190116
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 267
IP  - 2
DP  - 2018 Feb
TI  - Early and Late Complications After Surgery for MEN1-related Nonfunctioning 
      Pancreatic Neuroendocrine Tumors.
PG  - 352-356
LID - 10.1097/SLA.0000000000002050 [doi]
AB  - OBJECTIVE: To estimate short and long-term morbidity after pancreatic surgery for 
      multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic 
      neuroendocrine tumors (NF-pNETs). BACKGROUND: Fifty percent of the MEN1 patients 
      harbor multiple NF-pNETs. The decision to proceed to NF-pNET surgery is a balance 
      between the risk of disease progression versus the risk of surgery-related 
      morbidity. Currently, there are insufficient data on the surgical complications 
      after MEN1 NF-pNET surgery. METHODS: MEN1 patients diagnosed with a NF-pNET who 
      underwent surgery were selected from the DutchMEN1 study group database, 
      including >90% of the Dutch MEN1 population. Early postoperative complications, 
      new-onset diabetes mellitus, and exocrine pancreatic insufficiency were captured. 
      RESULTS: Sixty-one patients underwent NF-pNET surgery at 1 of the 8 Dutch 
      academic centers. Patients were young (median age 41 years) with low American 
      Society of Anesthesiologists scores. Median NF-pNET size on imaging was 22 mm 
      (3-157). Thirty-three percent (19/58) of the patients developed major 
      early-Clavien-Dindo grade III to IV-complications mainly consisting International 
      Study Group of Pancreatic Surgery grade B/C pancreatic fistulas. Twenty-three 
      percent of the patients (14/61) developed endocrine or exocrine pancreas 
      insufficiency. The development of major early postoperative complications was 
      independent of the NF-pNET tumor size. Twenty-one percent of the patients (12/58) 
      developed multiple major early complications. CONCLUSIONS: MEN1 NF-pNET surgery 
      is associated with high rates of major short and long-term complications. Current 
      findings should be taken into account in the shared decision-making process when 
      MEN1 NF-pNET surgery is considered.
FAU - Nell, Sjoerd
AU  - Nell S
AD  - Department of Endocrine Surgical Oncology and Endocrine Oncology, University 
      Medical Center Utrecht, Utrecht, the Netherlands.
FAU - Borel Rinkes, Inne H M
AU  - Borel Rinkes IHM
AD  - Department of Surgical Oncology and Endocrine Surgical Oncology, University 
      Medical Center Utrecht, Utrecht, the Netherlands.
FAU - Verkooijen, Helena M
AU  - Verkooijen HM
AD  - Imaging Division, University Medical Center Utrecht, Utrecht, the Netherlands.
FAU - Bonsing, Bert A
AU  - Bonsing BA
AD  - Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
FAU - van Eijck, Casper H
AU  - van Eijck CH
AD  - Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
FAU - van Goor, Harry
AU  - van Goor H
AD  - Department of Surgery, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - de Kleine, Ruben H J
AU  - de Kleine RHJ
AD  - Department of Hepato-Pancreatico-Biliary and Liver Transplantation, University of 
      Groningen, University Medical Center Groningen, Groningen, the Netherlands.
FAU - Kazemier, Geert
AU  - Kazemier G
AD  - Department of Surgery, VU University Medical Center, Amsterdam, the Netherlands.
FAU - Nieveen van Dijkum, Elisabeth J
AU  - Nieveen van Dijkum EJ
AD  - Department of Surgery, Academic Medical Center, Amsterdam, the Netherlands.
FAU - Dejong, Cornelis H C
AU  - Dejong CHC
AD  - Department of Surgery, Maastricht University Medical Center, Maastricht, the 
      Netherlands.
FAU - Valk, Gerlof D
AU  - Valk GD
AD  - Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Vriens, Menno R
AU  - Vriens MR
AD  - Department of Endocrine Surgical Oncology, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
CN  - DMSG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
RN  - Non functioning pancreatic endocrine tumor
SB  - IM
MH  - Adult
MH  - Aged
MH  - Databases, Factual
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/*surgery
MH  - *Pancreaticoduodenectomy
MH  - Postoperative Complications/*epidemiology
MH  - Retrospective Studies
EDAT- 2016/11/05 06:00
MHDA- 2019/01/17 06:00
CRDT- 2016/11/05 06:00
PHST- 2016/11/05 06:00 [pubmed]
PHST- 2019/01/17 06:00 [medline]
PHST- 2016/11/05 06:00 [entrez]
AID - 10.1097/SLA.0000000000002050 [doi]
PST - ppublish
SO  - Ann Surg. 2018 Feb;267(2):352-356. doi: 10.1097/SLA.0000000000002050.