PMID- 27812385
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210109
IS  - 2055-5822 (Print)
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 3
IP  - 2
DP  - 2016 Jun
TI  - Heart failure from heart muscle disease in childhood: a 5-10 year follow-up study 
      in the UK and Ireland.
PG  - 107-114
AB  - AIMS: Our original study, the first national prospective study of new-onset heart 
      failure from heart muscle disease in children, showed overall 1-year survival of 
      82%, and event (death or transplantation)-free survival of 66%. This study aimed 
      to evaluate 5 + year outcomes of this important cohort. METHODS AND RESULTS: All 
      centres in the UK and Ireland with 1-year event-free survivors participated 
      (n = 14). Anonymised data based on last hospital attendance and echocardiograms 
      were reviewed. The investigator was blinded to outcome at the time of echo 
      review. Of sixty-nine 1-year event-free survivors, data were obtained on 64, with 
      three lost to follow-up and two moved abroad. There were three deaths at 2.2, 3.3 
      and 9.0 years after presentation and one transplant, at 5.2 years. 
      Overall/event-free survival was 77%/62% at 5 years and 73%/59% at 10 years, 
      respectively. Overall and event-free survival conditional on 1-year survival was 
      94% at 5 years, and 89% at 10 years. For the 60 event-free survivors, median 
      (range) follow-up duration was 9.04 (5.0-10.33) years for those still under 
      review (n = 45), or time to discharge 5.25 (0.67-10.0) years (n = 15). 
      Fifty-eight were in New York Heart Association (NYHA) Class 1, and two in Class 
      2. Forty-one out of sixty had normal echocardiograms at last follow-up. 
      Predictors of better longer-term outcome were the same as for the original 1-year 
      follow-up study, namely, younger age and higher fractional shortening measurement 
      at presentation. CONCLUSIONS: Children who survive the first year following their 
      first presentation with significant heart failure from heart muscle disease have 
      a good longer-term outcome although there remains a small attrition rate.
FAU - Andrews, Rachel E
AU  - Andrews RE
AD  - Cardiothoracic Unit Great Ormond Street Hospital for Children NHS Foundation 
      Trust London UK.
FAU - Fenton, Matthew J
AU  - Fenton MJ
AD  - Cardiothoracic Unit Great Ormond Street Hospital for Children NHS Foundation 
      Trust London UK.
FAU - Dominguez, Troy
AU  - Dominguez T
AD  - Cardiothoracic Unit Great Ormond Street Hospital for Children NHS Foundation 
      Trust London UK.
FAU - Burch, Michael
AU  - Burch M
AD  - Cardiothoracic Unit Great Ormond Street Hospital for Children NHS Foundation 
      Trust London UK.
CN  - British Congenital Cardiac Association
LA  - eng
PT  - Journal Article
DEP - 20160124
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
PMC - PMC5066798
OTO - NOTNLM
OT  - Cardiomyopathy
OT  - Morbidity
OT  - Mortality
OT  - Myocarditis
OT  - Transplantation
EDAT- 2016/11/05 06:00
MHDA- 2016/11/05 06:01
PMCR- 2016/01/24
CRDT- 2016/11/05 06:00
PHST- 2015/09/28 00:00 [received]
PHST- 2015/12/02 00:00 [revised]
PHST- 2015/12/11 00:00 [accepted]
PHST- 2016/11/05 06:00 [pubmed]
PHST- 2016/11/05 06:01 [medline]
PHST- 2016/11/05 06:00 [entrez]
PHST- 2016/01/24 00:00 [pmc-release]
AID - EHF212082 [pii]
AID - 10.1002/ehf2.12082 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2016 Jun;3(2):107-114. doi: 10.1002/ehf2.12082. Epub 2016 Jan 24.