PMID- 27815510
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20180207
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 130
IP  - 24
DP  - 2016 Dec 1
TI  - Voltage-gated sodium channels and pain-related disorders.
PG  - 2257-2265
AB  - Voltage-gated sodium channels (VGSCs) are heteromeric transmembrane protein 
      complexes. Nine homologous members, SCN1A-11A, make up the VGSC gene family. 
      Sodium channel isoforms display a wide range of kinetic properties endowing 
      different neuronal types with distinctly varied firing properties. Among the 
      VGSCs isoforms, Nav1.7, Nav1.8 and Nav1.9 are preferentially expressed in the 
      peripheral nervous system. These isoforms are known to be crucial in the 
      conduction of nociceptive stimuli with mutations in these channels thought to be 
      the underlying cause of a variety of heritable pain disorders. This review 
      provides an overview of the current literature concerning the role of VGSCs in 
      the generation of pain and heritable pain disorders.
CI  - (c) 2016 The Author(s). published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Kanellopoulos, Alexandros H
AU  - Kanellopoulos AH
AD  - Molecular Nociception Group, Wolfson Institute for Biomedical Research, 
      University College London, Gower Street, London WC1E 6BT, U.K. 
      alexandros.kanellopoulos.13@ucl.ac.uk.
FAU - Matsuyama, Ayako
AU  - Matsuyama A
AD  - Molecular Nociception Group, Wolfson Institute for Biomedical Research, 
      University College London, Gower Street, London WC1E 6BT, U.K.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Voltage-Gated Sodium Channels)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Multigene Family
MH  - Neurons/metabolism
MH  - Pain/genetics/*metabolism
MH  - Voltage-Gated Sodium Channels/genetics/*metabolism
OTO - NOTNLM
OT  - Nav1.7
OT  - heritable disorders
OT  - pain
OT  - voltage-gated sodium channels
EDAT- 2016/11/07 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/11/06 06:00
PHST- 2016/01/14 00:00 [received]
PHST- 2016/09/15 00:00 [accepted]
PHST- 2016/11/06 06:00 [entrez]
PHST- 2016/11/07 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - CS20160041 [pii]
AID - 10.1042/CS20160041 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2016 Dec 1;130(24):2257-2265. doi: 10.1042/CS20160041.