PMID- 27815688
OWN - NLM
STAT- MEDLINE
DCOM- 20170629
LR  - 20211204
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 177
IP  - 2
DP  - 2017 Jun
TI  - Effect of Gestational Intake of Fisetin (3,3',4',7-Tetrahydroxyflavone) on 
      Developmental Methyl Mercury Neurotoxicity in F(1) Generation Rats.
PG  - 297-315
LID - 10.1007/s12011-016-0886-x [doi]
AB  - Methyl mercury (MeHg) is a developmental neurotoxin that causes irreversible 
      cognitive damage in offspring of gestationally exposed mothers. Currently, no 
      preventive drugs are established against MeHg developmental neurotoxicity. The 
      neuroprotective effect of gestational administration of a flavanoid against in 
      utero toxicity of MeHg is not explored much. Hence, the present study validated 
      the effect of a bioactive flavanoid, fisetin, on MeHg developmental neurotoxicity 
      outcomes in rat offspring at postnatal weaning age. Pregnant Wistar rats were 
      simultaneously given MeHg (1.5 mg/kg b.w.) and two doses of fisetin (10 and 
      50 mg/kg b.w. in two separate groups) orally from gestational day (GD) 5 till 
      parturition. Accordingly, after parturition, on postnatal day (PND) 24, weaning 
      F(1) generation rats were studied for motor and cognitive behavioural changes. 
      Biochemical and histopathological changes were also studied in the cerebral 
      cortex, cerebellum and hippocampus on PND 25. Administration of fisetin during 
      pregnancy prevented behavioural impairment due to transplacental MeHg exposure in 
      weaning rats. Fisetin decreased the levels of oxidative stress markers, increased 
      enzymatic and non-enzymatic antioxidant levels and increased the activity of 
      membrane-bound ATPases and cholinergic function in F(1) generation rats. In light 
      microscopic studies, fisetin treatment protected the specific offspring brain 
      regions from significant morphological aberrations. Between the two doses of 
      fisetin studied, 10 mg/kg b.w. was found to be more satisfactory and effective 
      than 50 mg/kg b.w. The present study shows that intake of fisetin during 
      pregnancy in rats ameliorated in utero MeHg exposure-induced neurotoxicity 
      outcomes in postnatal weaning F(1) generation rats.
FAU - Jacob, Sherin
AU  - Jacob S
AD  - Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic 
      Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu, 600 
      113, India.
FAU - Thangarajan, Sumathi
AU  - Thangarajan S
AD  - Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic 
      Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu, 600 
      113, India. drsumathi.bioscience@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20161104
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Flavonoids)
RN  - 0 (Flavonols)
RN  - 0 (Methylmercury Compounds)
RN  - 0 (Neuroprotective Agents)
RN  - C60TQU15XY (dimethyl mercury)
RN  - OO2ABO9578 (fisetin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/drug effects/metabolism
MH  - Cognitive Dysfunction/chemically induced/*drug therapy/prevention & control
MH  - Female
MH  - Flavonoids/administration & dosage/chemistry/*therapeutic use
MH  - Flavonols
MH  - Maternal Exposure/*adverse effects
MH  - Methylmercury Compounds/administration & dosage/*toxicity
MH  - Neuroprotective Agents/administration & dosage/chemistry/*therapeutic use
MH  - Neurotoxicity Syndromes/*drug therapy/*prevention & control
MH  - Oxidative Stress/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Toxicity Tests
OTO - NOTNLM
OT  - Cresyl violet
OT  - Fisetin
OT  - Gestational
OT  - Membrane-bound ATPases
OT  - Methyl mercury
OT  - Weaning
EDAT- 2016/11/07 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/11/06 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2016/10/24 00:00 [accepted]
PHST- 2016/11/07 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/11/06 06:00 [entrez]
AID - 10.1007/s12011-016-0886-x [pii]
AID - 10.1007/s12011-016-0886-x [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2017 Jun;177(2):297-315. doi: 10.1007/s12011-016-0886-x. 
      Epub 2016 Nov 4.