PMID- 27816171
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20170817
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 72
IP  - 2
DP  - 2017 Feb
TI  - Reliable exclusion of prognostically significant coronary disease in left 
      ventricular dysfunction by cardiac MRI.
PG  - 159-164
LID - S0009-9260(16)30411-1 [pii]
LID - 10.1016/j.crad.2016.10.006 [doi]
AB  - AIM: To assess the ability of cardiac magnetic resonance (CMR) to exclude 
      prognostically significant coronary artery disease (CAD) in patients with left 
      ventricular systolic dysfunction (LVSD). MATERIALS AND METHODS: A cohort of 
      patients who underwent both X-ray angiography and CMR since 2006 was reviewed 
      retrospectively. Records of those with European criteria for LVSD (left 
      ventricular ejection fraction [LVEF] <50% or LV end-diastolic volume index 
      [LVEDVI] >/=97 ml/m(2)) on CMR or transthoracic echo were analysed. The presence 
      and extent of subendocardial late gadolinium enhancement (LGE) was recorded with 
      the 17-segment model. The degree of coronary stenosis at X-ray angiography was 
      assessed visually and significant disease defined as stenosis of the LMS >/=50%, or 
      proximal left anterior descending >/=75%, or >/=70% in two main coronary vessels. 
      RESULTS: One hundred and sixteen patients were included. The mean age was 64 
      years and 78% were male. The mean LVEF was 40%. The prevalence of prognostic CAD 
      was 47%. The presence of subendocardial LGE detected prognostically significant 
      CAD with a sensitivity of 100% (95% CI: 94-100%) with no false-negative results. 
      CONCLUSIONS: The absence of subendocardial LGE on CMR reliably excludes 
      prognostic CAD in patients with LVSD.
CI  - Copyright (c) 2016 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Thompson, A C M
AU  - Thompson AC
AD  - Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, 
      County Durham, UK; School of Medicine, Pharmacy and Health, Durham University, 
      Queen's Campus, University Boulevard, Stockton-on-Tees, UK. Electronic address: 
      acmthompson@doctors.org.uk.
FAU - Crilley, J G
AU  - Crilley JG
AD  - Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, 
      County Durham, UK.
FAU - Wilson, D W
AU  - Wilson DW
AD  - School of Medicine, Pharmacy and Health, Durham University, Queen's Campus, 
      University Boulevard, Stockton-on-Tees, UK.
FAU - Hungin, A P S
AU  - Hungin AP
AD  - School of Medicine, Pharmacy and Health, Durham University, Queen's Campus, 
      University Boulevard, Stockton-on-Tees, UK.
FAU - Fuat, A
AU  - Fuat A
AD  - Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, 
      County Durham, UK; School of Medicine, Pharmacy and Health, Durham University, 
      Queen's Campus, University Boulevard, Stockton-on-Tees, UK.
FAU - Murphy, J J M
AU  - Murphy JJ
AD  - Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, 
      County Durham, UK; School of Medicine, Pharmacy and Health, Durham University, 
      Queen's Campus, University Boulevard, Stockton-on-Tees, UK.
LA  - eng
PT  - Journal Article
DEP - 20161102
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - Aged
MH  - Causality
MH  - Coronary Artery Disease/*complications/*diagnostic imaging
MH  - Diagnosis, Differential
MH  - False Positive Reactions
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/*etiology
EDAT- 2016/11/07 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/11/07 06:00
PHST- 2016/05/26 00:00 [received]
PHST- 2016/10/06 00:00 [revised]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2016/11/07 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/11/07 06:00 [entrez]
AID - S0009-9260(16)30411-1 [pii]
AID - 10.1016/j.crad.2016.10.006 [doi]
PST - ppublish
SO  - Clin Radiol. 2017 Feb;72(2):159-164. doi: 10.1016/j.crad.2016.10.006. Epub 2016 
      Nov 2.