PMID- 27816450
OWN - NLM
STAT- MEDLINE
DCOM- 20170613
LR  - 20171127
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 485
IP  - 2
DP  - 2017 Apr 1
TI  - IL-37 impairs host resistance to Listeria infection by suppressing macrophage 
      function.
PG  - 563-568
LID - S0006-291X(16)31850-2 [pii]
LID - 10.1016/j.bbrc.2016.11.002 [doi]
AB  - Listeria monocytogenes is a Gram-positive intracellular bacterium that was 
      transmitted through contaminated food and causes sepsis and even death. IL-37 has 
      been described as an important anti-inflammatory factor, but little is known 
      about the function of IL-37 in host defense against Liseria monocytogenes (Lm) 
      infection. In mice model of systemic infection, we found that mice treated with 
      IL-37 were more sensitive to Lm infection compared with PBS-treated mice. This 
      reduced resistance to Lm in IL-37-treated mice is accompanied with increased 
      bacterial burden and liver damage. Serum levels of colony-stimulating factors 
      were decreased in IL-37-treated mice. IL-37 treatment reduced bactericidal 
      ability of bone marrow derived macrophages (BMDMs) in vitro, which contribute to 
      the inability of IL-37-treated mice to combat Lm infection. Furthermore, 
      increased apoptosis was observed in Lm-infected macrophages treated with IL-37. 
      Increased macrophage apoptosis reduced percentage in liver macrophages was 
      observed in IL-37-treated mice following Lm infection. These results indicate the 
      negative regulatory effect of IL-37 on host resistance during immune defense 
      against Lm.
CI  - Copyright (c) 2016. Published by Elsevier Inc.
FAU - Zhao, Mengmeng
AU  - Zhao M
AD  - Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 
      200092, China.
FAU - Hu, Yongguang
AU  - Hu Y
AD  - Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 
      200092, China.
FAU - Shou, Juanjuan
AU  - Shou J
AD  - Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 
      200092, China.
FAU - Su, Shao Bo
AU  - Su SB
AD  - Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 
      200092, China; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic 
      Center, Sun Yat-sen University, Guangzhou, China.
FAU - Yang, Jianhua
AU  - Yang J
AD  - Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 
      200092, China.
FAU - Yang, Tianshu
AU  - Yang T
AD  - Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 
      200092, China. Electronic address: tianshuy@tongji.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161103
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Cytokines)
RN  - 0 (IL37 protein, human)
RN  - 0 (Interleukin-1)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Bacterial Load/drug effects
MH  - Cells, Cultured
MH  - Cytokines/blood
MH  - Disease Models, Animal
MH  - Disease Resistance/*drug effects/immunology
MH  - Flow Cytometry
MH  - Host-Pathogen Interactions/drug effects
MH  - Humans
MH  - Interleukin-1/*pharmacology
MH  - Listeria monocytogenes/*drug effects/immunology/physiology
MH  - Listeriosis/blood/*drug therapy/microbiology
MH  - Liver/drug effects/microbiology/pathology
MH  - Macrophages/*drug effects/immunology/microbiology
MH  - Mice, Inbred BALB C
MH  - Survival Analysis
OTO - NOTNLM
OT  - Apoptosis
OT  - Interleukin-37
OT  - Liseria monocytogenes
OT  - Macrophage
EDAT- 2016/11/07 06:00
MHDA- 2017/06/14 06:00
CRDT- 2016/11/07 06:00
PHST- 2016/10/13 00:00 [received]
PHST- 2016/11/01 00:00 [accepted]
PHST- 2016/11/07 06:00 [pubmed]
PHST- 2017/06/14 06:00 [medline]
PHST- 2016/11/07 06:00 [entrez]
AID - S0006-291X(16)31850-2 [pii]
AID - 10.1016/j.bbrc.2016.11.002 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2017 Apr 1;485(2):563-568. doi: 
      10.1016/j.bbrc.2016.11.002. Epub 2016 Nov 3.