PMID- 27816684
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 122
DP  - 2016 Dec
TI  - Role of telomeres and associated maintenance genes in Type 2 Diabetes Mellitus: A 
      review.
PG  - 92-100
LID - S0168-8227(16)30800-2 [pii]
LID - 10.1016/j.diabres.2016.10.015 [doi]
AB  - Type 2 Diabetes Mellitus (T2DM), a multifactorial complex disorder, is emerging 
      as a major cause of morbidity, mortality and socio-economic burden across the 
      world. Despite huge efforts in understanding genetics of T2DM, only  approximately 10% of the 
      genetic factors have been identified so far. Telomere attrition, a natural 
      phenomenon has recently emerged in understanding the pathophysiology of T2DM. It 
      has been indicated that Telomeres and associated pathways might be the critical 
      components in the disease etiology, though the mechanism(s) involved are not 
      clear. Recent Genome Wide (GWAS) and Candidate Gene Case-Control Association 
      Studies have also indicated an association of Telomere and associated pathways 
      related genes with T2DM. Single Nucleotide Polymorphisms (SNPs) in the telomere 
      maintenance genes: TERT, TERC, TNKS, CSNK2A2, TEP1, ACD, TRF1 and TRF2, have 
      shown strong association with telomere attrition in T2DM and its pathophysiology, 
      in these studies. However, the assessment has been made within limited 
      ethnicities (Caucasians, Han Chinese cohort and Punjabi Sikhs from South Asia), 
      warranting the study of such associations in different ethnic groups. Here, we 
      propose the possible mechanisms, in the light of existing knowledge, to 
      understand the association of T2DM with telomeres and associated pathways.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Sethi, Itty
AU  - Sethi I
AD  - Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno 
      Devi University Katra, J&K 182320, India.
FAU - Bhat, G R
AU  - Bhat GR
AD  - Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno 
      Devi University Katra, J&K 182320, India.
FAU - Singh, Vinod
AU  - Singh V
AD  - Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno 
      Devi University Katra, J&K 182320, India.
FAU - Kumar, Rakesh
AU  - Kumar R
AD  - Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno 
      Devi University Katra, J&K 182320, India.
FAU - Bhanwer, A J S
AU  - Bhanwer AJ
AD  - Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab 143005, 
      India.
FAU - Bamezai, Rameshwar N K
AU  - Bamezai RN
AD  - National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal 
      Nehru University, New Delhi 110067, India.
FAU - Sharma, Swarkar
AU  - Sharma S
AD  - Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno 
      Devi University Katra, J&K 182320, India. Electronic address: 
      swarkar.sharma@smvdu.ac.in.
FAU - Rai, Ekta
AU  - Rai E
AD  - Human Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno 
      Devi University Katra, J&K 182320, India. Electronic address: 
      ekta.rai@smvdu.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161021
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Telomere/*physiology
OTO - NOTNLM
OT  - Telomere attrition
OT  - Telomere maintenance genes
OT  - Telomeres
OT  - Type 2 Diabetes Mellitus (T2DM)
EDAT- 2016/11/07 06:00
MHDA- 2017/01/18 06:00
CRDT- 2016/11/07 06:00
PHST- 2016/02/23 00:00 [received]
PHST- 2016/10/09 00:00 [revised]
PHST- 2016/10/16 00:00 [accepted]
PHST- 2016/11/07 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
PHST- 2016/11/07 06:00 [entrez]
AID - S0168-8227(16)30800-2 [pii]
AID - 10.1016/j.diabres.2016.10.015 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2016 Dec;122:92-100. doi: 10.1016/j.diabres.2016.10.015. 
      Epub 2016 Oct 21.