PMID- 27816720
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20180114
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 60
DP  - 2017 Feb
TI  - Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform 
      neurofibroma. A report of 11 cases.
PG  - 167-173
LID - S0046-8177(16)30281-7 [pii]
LID - 10.1016/j.humpath.2016.10.010 [doi]
AB  - The authors present 11 cases of plexiform neurofibroma (PN) that featured a very 
      characteristic type of cell appearing as multivacuolated mucin-filled cells 
      (MMFC). The 11 cases were obtained after reviewing 109 cases of PN. Six out of 10 
      patients showed clinical features of neurofibromatosis type 1. The size of PN 
      ranged from 0.8 cm to 11.5 cm in the largest dimension. The lesions represented 
      classical PN in all cases with myxoid, hypocellular stroma. The MMFC were found 
      within the most myxoid tumorous nodules and were haphazardly located, typically 
      featuring a variably sized, multivacuolated cytoplasm divided by fine septa with 
      a small polygonal nucleus on one side, which was often compressed or slightly 
      indented by the cytoplasmic mucous substances. In many cases, the cells resembled 
      a soccer ball or a jellyfish. In all tested cases (n = 9), the MMFC stained for 
      CD34; six cases were also positive with GLUT-1 antibody, and two cases expressed 
      Claudin-1, whereas S-100 protein was negative. For comparison, we have reviewed a 
      series of randomly selected non-PN, malignant peripheral nerve sheath tumors 
      (MPNST) and of cases featuring non-neoplastic nerve trunks in our files, in which 
      no MMFC were encountered. MMFC seem to be unique to myxoid areas of PN, where 
      they occur in about 10% of cases. Their exact histogenesis is unclear but they 
      might represent an intermediate type of cell between perineurial cells and 
      fibroblasts. The awareness of this cell type in PN is especially important in 
      limited (small) biopsy specimens where their recognition may provide a clue for 
      the correct diagnosis.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Michal, Michael
AU  - Michal M
AD  - Department of Pathology, Charles University, Biomedical Center, Faculty of 
      Medicine in Plzen and Charles University Hospital Plzen, Alej Svobody 80, 304 60 
      Pilsen, Czech Republic. Electronic address: michael.michal@medima.cz.
FAU - Kazakov, Dmitry V
AU  - Kazakov DV
AD  - Department of Pathology, Charles University, Medical Faculty and Charles 
      University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
FAU - Hadravsky, Ladislav
AU  - Hadravsky L
AD  - Department of Pathology, Charles University, Third Medical Faculty and Charles 
      University Hospital Kralovske Vinohrady, Srobarova 50, 100 34 Prague, Czech 
      Republic.
FAU - Michalova, Kvetoslava
AU  - Michalova K
AD  - Department of Pathology, Charles University, Medical Faculty and Charles 
      University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
FAU - Rychly, Boris
AU  - Rychly B
AD  - Cytopathos, Limbova 5, 833 07, Bratislava 37, Slovakia.
FAU - Michal, Michal
AU  - Michal M
AD  - Department of Pathology, Charles University, Medical Faculty and Charles 
      University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161102
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CLDN1 protein, human)
RN  - 0 (Claudin-1)
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (Mucins)
RN  - 0 (SLC2A1 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, CD34/analysis
MH  - Biomarkers, Tumor/*analysis
MH  - Biopsy
MH  - Child
MH  - Claudin-1/analysis
MH  - Female
MH  - Glucose Transporter Type 1/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Mucins/*analysis
MH  - Neurofibroma, Plexiform/*chemistry/pathology
MH  - Neurofibromatosis 1/*metabolism/pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Vacuoles/*chemistry/pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Multivacuolated lipoblast- like cells
OT  - Multivacuolated mucin-filled cells
OT  - Perineurial cells
OT  - Plexiform neurofibroma
OT  - Soft tissue
EDAT- 2016/11/07 06:00
MHDA- 2017/08/29 06:00
CRDT- 2016/11/07 06:00
PHST- 2016/08/15 00:00 [received]
PHST- 2016/10/09 00:00 [revised]
PHST- 2016/10/14 00:00 [accepted]
PHST- 2016/11/07 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
PHST- 2016/11/07 06:00 [entrez]
AID - S0046-8177(16)30281-7 [pii]
AID - 10.1016/j.humpath.2016.10.010 [doi]
PST - ppublish
SO  - Hum Pathol. 2017 Feb;60:167-173. doi: 10.1016/j.humpath.2016.10.010. Epub 2016 
      Nov 2.