PMID- 27817914
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20220129
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 124
IP  - 1
DP  - 2017 Jan
TI  - Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen: A 
      Comparison of Cases with and without Visual Field Loss.
PG  - 66-73
LID - S0161-6420(16)31366-5 [pii]
LID - 10.1016/j.ophtha.2016.09.022 [doi]
AB  - PURPOSE: Enhanced depth imaging (EDI) spectral-domain optical coherence 
      tomography (SD OCT) has been recognized as the most sensitive tool to diagnose 
      optic nerve head drusen (ONHD). The relationship between OCT characteristics and 
      visual loss has not been well documented. This study compares EDI SD 
      OCT-determined morphologic characteristics of drusen in eyes with or without 
      visual field (VF) defects. DESIGN: Descriptive study of patients attending the 
      neuro-ophthalmology service of Moorfields Eye Hospital between January 2013 and 
      October 2014. SUBJECTS: Patients with diagnosed ONHD and EDI SD OCT imaging of 
      the optic nerve head. METHODS: Eyes with and without VF defects were compared 
      with regard to retinal nerve fiber layer (RNFL) thickness, drusen morphology, 
      size, extent, visibility on funduscopy, ultrasound, and fundus autofluorescence. 
      MAIN OUTCOME MEASURES: Difference in OCT characteristics of ONHD between patients 
      with or without VF defects. RESULTS: Of 38 patients, 69 eyes with ONHD were 
      included. Thirty-three eyes had a normal VF with average mean deviation 
      (MD) -0.96 (+/-1.2) dB and pattern standard deviation (PSD) 1.6 (+/-0.3) dB (group 
      I), and 36 eyes had VF defects with MD -13.7 (+/-10.4) dB and PSD 7.2 (+/-3.6) dB 
      (group II). Mean global RNFL thickness was 62 (+/-20.9) mum in the latter group and 
      99.0 (+/-12.9) mum in group I. In group I, the predominant drusen type 
      was peripapillary drusen, of variable size. In group II, most eyes had confluent 
      (P < 0.02) and large (>500 mum; P < 0.003) drusen, and drusen were more commonly 
      visible on funduscopy (P = 0.001), ultrasound (P = 0.013), and autofluorescence 
      (P = 0.002). Differences between the 2 groups reached statistical significance in 
      a clustered analysis. RNFL thinning and autofluorescence showed relative sparing 
      of the temporal sector. Sixty-four percent of patients with a VF defect in 1 eye 
      also had a VF defect in their fellow eye. CONCLUSIONS: Drusen size and drusen 
      type as classified by OCT morphologic characteristics are significantly different 
      in patients with or without VF defects. Confluent, large, and autofluorescent 
      drusen were more commonly found in patients with VF defects. These findings may 
      assist in clarifying how drusen give rise to visual loss, which is currently not 
      known.
CI  - Copyright (c) 2016 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Traber, Ghislaine L
AU  - Traber GL
AD  - Moorfields Eye Hospital, London, United Kingdom; Department of Ophthalmology, 
      University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic 
      address: ghislaine.traber@usz.ch.
FAU - Weber, Konrad P
AU  - Weber KP
AD  - Department of Ophthalmology, University Hospital Zurich, University of Zurich, 
      Zurich, Switzerland; Department of Neurology, University Hospital Zurich, 
      University of Zurich, Zurich, Switzerland.
FAU - Sabah, Mazen
AU  - Sabah M
AD  - Moorfields Eye Hospital, London, United Kingdom.
FAU - Keane, Pearse A
AU  - Keane PA
AD  - Moorfields Eye Hospital, London, United Kingdom; UCL Institute of Ophthalmology, 
      London, United Kingdom.
FAU - Plant, Gordon T
AU  - Plant GT
AD  - Moorfields Eye Hospital, London, United Kingdom; The National Hospital for 
      Neurology and Neurosurgery, London, United Kingdom; St Thomas' Hospital, London, 
      United Kingdom.
LA  - eng
GR  - CS-2014-14-023/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20161103
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
CIN - Ophthalmology. 2017 Jun;124(6):e55-e56. PMID: 28528842
CIN - Ophthalmology. 2017 Jun;124(6):e56. PMID: 28528843
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*diagnostic imaging
MH  - Optic Disk Drusen/*diagnostic imaging/*physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Vision Disorders/*physiopathology
MH  - Visual Acuity
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
EDAT- 2016/11/08 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/11/08 06:00
PHST- 2016/07/06 00:00 [received]
PHST- 2016/09/02 00:00 [revised]
PHST- 2016/09/16 00:00 [accepted]
PHST- 2016/11/08 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/11/08 06:00 [entrez]
AID - S0161-6420(16)31366-5 [pii]
AID - 10.1016/j.ophtha.2016.09.022 [doi]
PST - ppublish
SO  - Ophthalmology. 2017 Jan;124(1):66-73. doi: 10.1016/j.ophtha.2016.09.022. Epub 
      2016 Nov 3.