PMID- 27818475
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20170206
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 57
IP  - 6
DP  - 2016 Dec 2
TI  - Sector-Based Assessment of Infarct Size on Late-Gadolinium-Enhancement MRI in a 
      Mouse Model of Acute Myocardial Infarction.
PG  - 736-741
AB  - Scoring of myocardial infarction (MI) disease extent in cardiac magnetic 
      resonance (CMR) images has been generally presented in terms of area-based 
      infarct size. However, gradual thinning of the infarcted wall and compensatory 
      hypertrophy of the noninfarcted remote wall during left ventricular (LV) 
      remodeling after MI complicate the accuracy of infarct size measurement. In this 
      study, we measured and compared infarct sizes in mice on late gadolinium 
      enhancement (LGE) images using area-, length-, and radial sector-based methods.MI 
      was induced by permanent ligation of the left coronary artery (n = 6). LGE images 
      were acquired 30 minutes after intravenous injection of Gd-DTPA-BMA. Percentages 
      of infarct size (%Area, %Length, and %Sector) on the LGE images were calculated 
      and compared with histological findings.Infarct sizes obtained by an area-based 
      approach were smaller than those obtained by other measurements. The area-based 
      approach underestimated infarct size compared with the length-based approach. 
      Most infarct sizes measured by each method demonstrated a similar trend, with 
      maximum values determined by sector-based measurements using a mean + SD 
      threshold. Spearman's rank correlation coefficients indicated that the 3 
      measurements were strongly correlated (P < 0.05) to each other. Significant 
      differences and trends were observed between sector-based infarct sizes with 
      different thresholds when 16 or more sectors were used.In conclusion, our study 
      demonstrated that methods used for the histological calculation of infarct size 
      could be applied to CMR analysis. Moreover, our results showed a similar trend to 
      histological assessment. Sector-based CMR approaches can be useful for infarct 
      size measurement.
FAU - Park, Cheongsoo
AU  - Park C
AD  - Bio-imaging Research Team, Korea Basic Science Institute.
FAU - Park, Eun-Hye
AU  - Park EH
FAU - Chang, Kiyuk
AU  - Chang K
FAU - Hong, Kwan Soo
AU  - Hong KS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161104
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Animals
MH  - *Contrast Media
MH  - Disease Models, Animal
MH  - *Gadolinium DTPA
MH  - *Image Enhancement
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myocardial Infarction/*diagnostic imaging/pathology
MH  - Reproducibility of Results
EDAT- 2016/11/08 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/11/08 06:00
PHST- 2016/11/08 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
PHST- 2016/11/08 06:00 [entrez]
AID - 10.1536/ihj.16-052 [doi]
PST - ppublish
SO  - Int Heart J. 2016 Dec 2;57(6):736-741. doi: 10.1536/ihj.16-052. Epub 2016 Nov 4.