PMID- 27819155
OWN - NLM
STAT- MEDLINE
DCOM- 20170213
LR  - 20181202
IS  - 1744-7666 (Electronic)
IS  - 1465-6566 (Linking)
VI  - 17
IP  - 18
DP  - 2016 Dec
TI  - Drugs for the treatment of pediatric type 2 diabetes mellitus and related 
      co-morbidities.
PG  - 2449-2460
AB  - The continuing global epidemic of obesity in adolescents has raised the 
      prevalence of type 2 diabetes mellitus (T2DM). Despite the wealth of information 
      concerning T2DM in adults, rare data are available targeting treatment of T2DM in 
      pediatric. Areas covered: This article has reviewed clinical practice guidelines, 
      particularly the American Diabetes Association and the Pediatric Endocrine 
      Society consensus, jointly with clinical trial data available in databases with 
      respect to the use of available pharmacological options to treat T2DM and its 
      complications in youth. Expert opinion: The use of other pharmacological 
      treatments of T2DM in addition to metformin and insulin entails several problems. 
      Since rare studies have been conducted on the medications available to manage 
      T2DM in children, treating them may be more difficult than that of adults. It 
      needs longer and larger size clinical trials along with better pharmacological 
      agents to affect various pathophysiological mechanisms of diabetes. Meanwhile, 
      the efficacy and safety of combinations therapies should be completed in 
      preclinical and clinical phases.
FAU - Tabatabaei-Malazy, Ozra
AU  - Tabatabaei-Malazy O
AD  - a Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute , Tehran University of Medical Sciences , Tehran , Iran.
AD  - b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute , Tehran University of Medical Sciences , Tehran , 
      Iran.
FAU - Nikfar, Shekoufeh
AU  - Nikfar S
AD  - b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute , Tehran University of Medical Sciences , Tehran , 
      Iran.
AD  - c Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.
FAU - Larijani, Bagher
AU  - Larijani B
AD  - b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute , Tehran University of Medical Sciences , Tehran , 
      Iran.
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
AD  - b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute , Tehran University of Medical Sciences , Tehran , 
      Iran.
AD  - d Toxicology and Diseases Group, Pharmaceutical Sciences Research Center , Tehran 
      University of Medical Sciences , Tehran , Iran.
AD  - e Department of Toxicology and Pharmacology, Faculty of Pharmacy, and 
      Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , 
      Tehran , Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161121
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/methods
MH  - Comorbidity
MH  - Diabetes Complications/diagnosis/drug therapy/epidemiology
MH  - Diabetes Mellitus, Type 2/diagnosis/*drug therapy/*epidemiology
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/therapeutic use
MH  - Metformin/therapeutic use
MH  - Obesity/diagnosis/*drug therapy/*epidemiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Pediatric
OT  - treatment
OT  - type 2 diabetes
EDAT- 2016/11/08 06:00
MHDA- 2017/02/14 06:00
CRDT- 2016/11/08 06:00
PHST- 2016/11/08 06:00 [pubmed]
PHST- 2017/02/14 06:00 [medline]
PHST- 2016/11/08 06:00 [entrez]
AID - 10.1080/14656566.2016.1258057 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2016 Dec;17(18):2449-2460. doi: 
      10.1080/14656566.2016.1258057. Epub 2016 Nov 21.