PMID- 27819485
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20230926
IS  - 1537-4424 (Electronic)
IS  - 1537-4416 (Print)
IS  - 1537-4416 (Linking)
VI  - 48
IP  - sup1
DP  - 2019
TI  - Pilot Randomized Controlled Trial of Omega-3 and Individual-Family 
      Psychoeducational Psychotherapy for Children and Adolescents With Depression.
PG  - S105-S118
LID - 10.1080/15374416.2016.1233500 [doi]
AB  - The goal of this study is to evaluate feasibility and estimate effect sizes of 
      omega-3 fatty acids (Omega3), individual-family psychoeducational psychotherapy 
      (PEP), their combination, and moderating effects of maternal depression and 
      psychosocial stressors in youth with depression. In a pilot 2 x 2 randomized 
      controlled trial, 72 youth (ages 7-14; 57% Caucasian, 57% male) with major 
      depression, dysthymia, or depression not otherwise specified were randomized to 
      12 weeks of Omega3, PEP+placebo, Omega3+PEP, or placebo. Omega3 versus placebo was 
      double-masked. Evaluators masked to condition assessed depressive severity at 
      baseline (randomization) and at 2, 4, 6, 9, and 12 weeks using the Children's 
      Depression Rating Scale-Revised. Side effects were either absent or mild. PEP was 
      administered with 74% fidelity. Remission was 77%, Omega3+PEP; 61%, PEP+placebo; 44%, 
      Omega3; 56%, placebo. Intent-to-treat analyses found small to medium effects of 
      combined treatment (d = .29) and Omega3 monotherapy (d = .42), but negligible effect 
      for PEP+placebo (d < .10), all compared to placebo alone. Relative to placebo, 
      youth with fewer social stressors responded better to Omega3 (p = .04), PEP 
      (p = .028), and their combination (p = .035), and those with maternal depression 
      responded better to PEP (p = .020) than did those without maternal depression. 
      Remission rates were favorable compared to other studies of psychotherapy and 
      comparable to an existing randomized controlled trial of Omega3; results warrant 
      further evaluation in a larger sample. Omega3 was well tolerated. Active treatments 
      show significantly more placebo-controlled depression improvement in the context 
      of maternal depression and fewer stressors, suggesting that they may benefit 
      depression with a more endogenous than environmental origin.
FAU - Fristad, Mary A
AU  - Fristad MA
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Vesco, Anthony T
AU  - Vesco AT
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Young, Andrea S
AU  - Young AS
AUID- ORCID: 0000-0002-8486-0643
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Healy, K Zachary
AU  - Healy KZ
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Nader, Elias S
AU  - Nader ES
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Gardner, William
AU  - Gardner W
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Seidenfeld, Adina M
AU  - Seidenfeld AM
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Wolfson, Hannah L
AU  - Wolfson HL
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
FAU - Arnold, L Eugene
AU  - Arnold LE
AD  - a Department of Psychiatry and Behavioral Health , The Ohio State University 
      Wexner Medical Center.
LA  - eng
GR  - R34 MH085875/MH/NIMH NIH HHS/United States
GR  - R34 MH090148/MH/NIMH NIH HHS/United States
GR  - UL1 RR025755/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20161107
PL  - England
TA  - J Clin Child Adolesc Psychol
JT  - Journal of clinical child and adolescent psychology : the official journal for 
      the Society of Clinical Child and Adolescent Psychology, American Psychological 
      Association, Division 53
JID - 101133858
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Depression/*drug therapy/*therapy
MH  - Fatty Acids, Omega-3/pharmacology/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Psychotherapy/*methods
MH  - Treatment Outcome
PMC - PMC6066443
MID - NIHMS1500654
EDAT- 2016/11/08 06:00
MHDA- 2020/05/28 06:00
PMCR- 2020/01/01
CRDT- 2016/11/08 06:00
PHST- 2016/11/08 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2016/11/08 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.1080/15374416.2016.1233500 [doi]
PST - ppublish
SO  - J Clin Child Adolesc Psychol. 2019;48(sup1):S105-S118. doi: 
      10.1080/15374416.2016.1233500. Epub 2016 Nov 7.