PMID- 27821299
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20181202
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 151
DP  - 2016 Dec
TI  - Biomarkers related with seizure risk in glioma patients: A systematic review.
PG  - 113-119
LID - S0303-8467(16)30359-6 [pii]
LID - 10.1016/j.clineuro.2016.10.001 [doi]
AB  - Increasing evidence indicates that genetic biomarkers play important roles in the 
      development of glioma-associated seizures. Thus, we performed a systematic review 
      to summarise biomarkers that are associated with seizures in glioma patients. An 
      electronic literature search of public databases (PubMed, Embase and Medline) was 
      performed using the keywords glioma, seizure and epilepsy. A totall of 26 
      eligible studies with 2224 cases were included in this systematic review of 
      publications to 20 June, 2016. Genetic biomarkers such as isocitrate 
      dehydrogenase 1 (IDH1) mutations, low expression of excitatory amino acid 
      transporter 2 (EAAT2), high xCT expression, overexpression of adenosine kinase 
      (ADK) and low expression of very large G-protein-coupled receptor-1 (VLGR1) are 
      primarily involved in synaptic transmission, whereas BRAF mutations, epidermal 
      growth factor receptor (EGFR) amplification, miR-196b expression and low ki-67 
      expression are associated with regulation of cell proliferation. However, there 
      is limited evidence regarding the roles of RAD50 interactor 1 (RINT1) and olig2 
      in epileptogenesis among glioma patients. Glioma-related seizure was related to 
      the dysfunction of tumor microenvironment. Our findings may provide new 
      mechanistic insights into targeted therapy for glioma-related seizures and may 
      result in the development of multi-target therapies.
CI  - Copyright A(c) 2016 Elsevier B.V. All rights reserved.
FAU - Zhou, Xing-Wang
AU  - Zhou XW
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China.
FAU - Wang, Xiang
AU  - Wang X
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China.
FAU - Yang, Yuan
AU  - Yang Y
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China.
FAU - Luo, Jie-Wen
AU  - Luo JW
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China.
FAU - Dong, Hui
AU  - Dong H
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China.
FAU - Liu, Yan-Hui
AU  - Liu YH
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China.
FAU - Mao, Qing
AU  - Mao Q
AD  - Department of Neurosurgery, West China Hospital, Si Chuan University, Chengdu 
      610041, China. Electronic address: maoqing@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20161102
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Biomarkers
MH  - Brain Neoplasms/*complications
MH  - Glioma/*complications
MH  - Humans
MH  - Seizures/*diagnosis/*etiology
OTO - NOTNLM
OT  - Biomarker
OT  - Epilepsy
OT  - Glioma
OT  - Seizure
EDAT- 2016/11/09 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/11/09 06:00
PHST- 2016/08/01 00:00 [received]
PHST- 2016/10/03 00:00 [accepted]
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/11/09 06:00 [entrez]
AID - S0303-8467(16)30359-6 [pii]
AID - 10.1016/j.clineuro.2016.10.001 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2016 Dec;151:113-119. doi: 10.1016/j.clineuro.2016.10.001. 
      Epub 2016 Nov 2.