PMID- 2782141
OWN - NLM
STAT- MEDLINE
DCOM- 19891026
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 248
DP  - 1989
TI  - The hydrogen gas clearance method for liver blood flow examination: inhalation or 
      local application of hydrogen?
PG  - 141-9
AB  - The combined method of hydrogen inhalation and local hydrogen production enable 
      the determination of hepatic blood flow (HBF) and local hepatic blood flow 
      (LHBF). LHBF was registered within a small superficial tissue volume of 0.5 mm in 
      diameter by means of a multi-wire electrode having 200 microns producing and 100 
      microns measuring wires arranged within less than 300 microns distance between 
      the measuring wires. The feeding current for hydrogen production was 1 microA, 
      the potential less than 10 V. The clearance in response to inhalation was 
      registered by means of the same measuring electrodes within the same tissue 
      volume. Spontaneously breathing rats (Wistar-Fromter strain, 180-230 g bw, N = 
      19, ketamin-xylazine anesthesia, artificial respiration) showed the following 
      flow values: HBF +/- SD = 0.50 +/- 0.26 ml/g.min, n = 48 registrations; LHBF +/- 
      SD = 4.66 +/- 2.13 ml/g.min, n = 43. The validity of the combined method is 
      demonstrated in the LHBF/HBF graph which summarizes the data of hemorrhagic and 
      control animals, m = 0.1 and yo = 0.001. The correlation coefficient of r = 0.685 
      shows a reasonable correlation of the combined data despite the wide scattering 
      of the individual values.
FAU - Metzger, H P
AU  - Metzger HP
AD  - Arbeitsbereich Biosignalverarbeitung und Kybernetik, Medizinische Hochschule, 
      Hannover, FRG.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Animals
MH  - Electrochemistry/instrumentation/methods
MH  - Electrodes
MH  - Hydrogen
MH  - Kinetics
MH  - Liver/*blood supply
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Regional Blood Flow
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/978-1-4684-5643-1_18 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 1989;248:141-9. doi: 10.1007/978-1-4684-5643-1_18.