PMID- 27821640
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20180612
IS  - 1468-2982 (Electronic)
IS  - 0333-1024 (Linking)
VI  - 37
IP  - 11
DP  - 2017 Oct
TI  - Familial history of migraine influences habituation of visual evoked potentials.
PG  - 1082-1087
LID - 10.1177/0333102416673207 [doi]
AB  - Background Lack of habituation of visual evoked potentials (VEP) is a common 
      finding in migraine patients between attacks. Previous studies have suggested an 
      electrophysiological familial aggregation pattern associated with migraine. The 
      aim of this study was to evaluate the influence of a positive familial history of 
      migraine on VEP amplitude and habituation. Methods We recorded six blocks of 100 
      VEP during continuous pattern-reversal stimulation in 30 patients with migraine 
      between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree 
      relative suffering from migraine (HVm) and 15 had not (HV). Results Both MO and 
      HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 
      first block amplitudes, compared to HV (habituation slope: MO = 0.033, 
      HVm = 0.021, HV = -0.025, HV vs. MO p = 0.002, HV vs. HVm p = 0.036; mean N1-P1 
      amplitude in the first block: MO = 9.08 microV, HVm = 9.29 microV, HV = 12.19 microV. HV vs. 
      MO p = 0.041, HV vs. HVm p = 0.076). The first block N1-P1 amplitude was 
      negatively correlated with the habituation slope for both MO (rho = -.44, 
      p = 0.015) and HVm (rho = -.56, p = 0.031) while no significant correlation was 
      found in HV (rho = .17, p = 0.53). There were no differences in VEP latencies 
      between the groups. Conclusions Our study suggests that lack of habituation of 
      visual evoked potentials is probably a genetically determined endophenotypic 
      trait that is associated with both migraine and migraine susceptibility. We 
      hypothesize that genetic diversity of populations could account for some of the 
      discrepancies between electrophysiological studies performed in migraine and for 
      interindividual variations among the subgroups.
FAU - Lisicki, Marco
AU  - Lisicki M
AD  - 1 Headache Research unit, University Department of Neurology CHR, Liege, Belgium.
FAU - Ruiz-Romagnoli, Emiliano
AU  - Ruiz-Romagnoli E
AD  - 2 Department of Neurology, Reina Fabiola University Clinic, Catholic University 
      of Cordoba, Cordoba, Argentina.
FAU - D'Ostilio, Kevin
AU  - D'Ostilio K
AD  - 1 Headache Research unit, University Department of Neurology CHR, Liege, Belgium.
FAU - Piedrabuena, Raul
AU  - Piedrabuena R
AD  - 2 Department of Neurology, Reina Fabiola University Clinic, Catholic University 
      of Cordoba, Cordoba, Argentina.
FAU - Giobellina, Roberto
AU  - Giobellina R
AD  - 2 Department of Neurology, Reina Fabiola University Clinic, Catholic University 
      of Cordoba, Cordoba, Argentina.
FAU - Schoenen, Jean
AU  - Schoenen J
AD  - 1 Headache Research unit, University Department of Neurology CHR, Liege, Belgium.
FAU - Magis, Delphine
AU  - Magis D
AD  - 1 Headache Research unit, University Department of Neurology CHR, Liege, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20161112
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
SB  - IM
CIN - Cephalalgia. 2018 Apr;38(5):1009-1010. PMID: 28750587
MH  - Adult
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Habituation, Psychophysiologic/*physiology
MH  - Humans
MH  - Male
MH  - Migraine Disorders/genetics/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Migraine
OT  - genetics
OT  - visual evoked potentials
EDAT- 2016/11/09 06:00
MHDA- 2018/06/13 06:00
CRDT- 2016/11/09 06:00
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2016/11/09 06:00 [entrez]
AID - 0333102416673207 [pii]
AID - 10.1177/0333102416673207 [doi]
PST - ppublish
SO  - Cephalalgia. 2017 Oct;37(11):1082-1087. doi: 10.1177/0333102416673207. Epub 2016 
      Nov 12.