PMID- 27821814
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20221207
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 49
DP  - 2016 Dec 6
TI  - Genetic susceptibility of eight nonsynonymous polymorphisms in HLA-DRB1 gene to 
      hepatocellular carcinoma in Han Chinese.
PG  - 80935-80942
LID - 10.18632/oncotarget.13111 [doi]
AB  - Backgrounds and Objective: Mounting evidence suggests that human leukocyte 
      antigen (HLA) plays a central role in anti-virus and tumor defense. To test 
      whether genetic variation in HLA-DRB1 gene, a key component of HLA system, can 
      predict its predisposition to hepatocellular carcinoma (HCC), we thereby 
      conducted an association study by genotyping 8 nonsynonymous polymorphisms in 
      HLA-DRB1 gene among 257 HCC patients and 264 controls. RESULTS: All polymorphisms 
      respected the Hardy-Weinberg equilibrium. The genotypes and alleles of rs17879599 
      differed significantly between patients and controls after Bonferroni correction 
      (both P < 0.001), and the power to detect this significance was 94.4%. After 
      adjusting for age, gender, smoking, drinking and hepatitis infection, the mutant 
      allele of rs17879702 was significantly associated with an increased risk for HCC 
      under additive (odds ratio [OR] = 2.12, 95% confidence interval [CI]: 1.20-4.02, 
      P = 0.004) and dominant (OR = 2.51, 95% CI: 1.39-2.96, P = 0.004) models. 
      Haplotype analysis indicated that haplotype A-T-C-T-G-C-T-A (alleles ordered by 
      rs199514452, rs201540428, rs201614260, rs17879702, rs17880292, rs17879599, 
      rs17424145 and rs35445101) was overrepresented in patients and enhanced 
      predisposition to HCC (adjusted OR = 2.72, 95% CI: 1.24-5.78, P = 0.004). In 
      cumulative analysis, carriers of 7-9 unfavorable alleles had a 2.41-fold (95% CI: 
      1.18-4.92, P = 0.016) increased risk for HCC after adjusting for confounding 
      factors relative to those possessing 4 or less unfavorable alleles. MATERIALS AND 
      METHODS: Genotypes were determined by ligase detection reaction. HCC patients 
      were newly diagnosed, histopathologically confirmed or previously untreated and 
      controls were cancer-free. CONCLUSIONS: Our findings suggest an independent 
      leading contribution of rs17879599 in the 2nd exon of HLA-DRB1 gene to HCC risk 
      in Han Chinese.
FAU - Shi, Yanhui
AU  - Shi Y
AD  - Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, 
      Heilongjiang, China.
FAU - Zhai, Weiyu
AU  - Zhai W
AD  - Department of Pharmacy, The First Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar, Heilongjiang, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, 
      China.
FAU - Zhao, Dongmei
AU  - Zhao D
AD  - Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, 
      Heilongjiang, China.
FAU - Jin, He
AU  - Jin H
AD  - Department of Cardiology, Hospital of Traditional Chinese Medicine of Qiqihar, 
      Qiqihar, Heilongjiang, China.
FAU - Wang, Yuefei
AU  - Wang Y
AD  - Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, 
      China.
FAU - Zhang, Jidong
AU  - Zhang J
AD  - Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, 
      Heilongjiang, China.
FAU - An, Hongjun
AU  - An H
AD  - Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, 
      Heilongjiang, China.
FAU - Fu, Zhongze
AU  - Fu Z
AD  - Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, 
      Heilongjiang, China.
FAU - Zhao, Kun
AU  - Zhao K
AD  - Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, 
      China.
FAU - Lu, Changzhu
AU  - Lu C
AD  - Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, 
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Hepatocellular/ethnology/*genetics/pathology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - China
MH  - Exons
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Liver Neoplasms/ethnology/*genetics/pathology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC5348366
OTO - NOTNLM
OT  - Han Chinese
OT  - genetic predisposition
OT  - hepatocellular carcinoma
OT  - human leukocyte antigen
OT  - non-synonymous polymorphism
COIS- CONFLICTS OF INTEREST None declared.
EDAT- 2016/11/09 06:00
MHDA- 2018/02/24 06:00
PMCR- 2016/12/06
CRDT- 2016/11/09 06:00
PHST- 2016/09/27 00:00 [received]
PHST- 2016/10/28 00:00 [accepted]
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
PHST- 2016/11/09 06:00 [entrez]
PHST- 2016/12/06 00:00 [pmc-release]
AID - 13111 [pii]
AID - 10.18632/oncotarget.13111 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Dec 6;7(49):80935-80942. doi: 10.18632/oncotarget.13111.