PMID- 27822481
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Association between -308G/A TNFA Polymorphism and Susceptibility to Type 2 
      Diabetes Mellitus: A Systematic Review.
PG  - 6309484
LID - 6309484
AB  - Diabetes mellitus (DM) is considered to be a worldwide epidemic disease and its 
      type 2 form comprises more than 95% of all cases. Tumor necrosis factor-alpha 
      (TNF-alpha) is a proinflammatory cytokine. Its dysregulation has been implicated in a 
      variety of human diseases, including type 2 diabetes mellitus (T2DM). The control 
      of expression of this cytokine is associated with insulin resistance and has a 
      strong genetic influence. In order to understand this relationship, the 
      literature from all case-control studies since 2000 to date was reviewed. The 
      genotypes frequency results presented in ten publications with different 
      ethnicities were compared. The correlation between the TNFA promoter genotypes 
      and the risk of developing T2DM remains controversial due to the many 
      discrepancies between the different studies available. Ethnic differences may 
      play a role in these conflicting results, since the distribution of TNFA promoter 
      polymorphisms is distinctive between individuals of dissimilar racial origin. 
      Hence, although the relationship between T2DM incidence and presence of 
      polymorphisms at position -308 of the TNFA gene is not entirely clear, the 
      results of these studies suggest the need for further investigation.
FAU - Luna, Geisa Izetti
AU  - Luna GI
AUID- ORCID: 0000-0003-4651-5694
AD  - Programa de Pos-Graduacao em Saude Coletiva, Universidade de Brasilia, Brasilia, 
      DF, Brazil.
FAU - da Silva, Izabel Cristina Rodrigues
AU  - da Silva IC
AUID- ORCID: 0000-0002-6836-3583
AD  - FCE, Universidade de Brasilia, Brasilia, DF, Brazil.
FAU - Sanchez, Mauro Niskier
AU  - Sanchez MN
AD  - Programa de Pos-Graduacao em Saude Coletiva, Universidade de Brasilia, Brasilia, 
      DF, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20161016
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC5086378
EDAT- 2016/11/09 06:00
MHDA- 2017/06/07 06:00
PMCR- 2016/10/16
CRDT- 2016/11/09 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/07/12 00:00 [revised]
PHST- 2016/09/14 00:00 [accepted]
PHST- 2016/11/09 06:00 [entrez]
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2016/10/16 00:00 [pmc-release]
AID - 10.1155/2016/6309484 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:6309484. doi: 10.1155/2016/6309484. Epub 2016 Oct 16.