PMID- 27822744
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1869-5760 (Print)
IS  - 1869-5760 (Electronic)
IS  - 1869-5760 (Linking)
VI  - 6
IP  - 1
DP  - 2016 Dec
TI  - Bevacizumab for paradoxical worsening treatment adjunct in HIV patient with 
      choroidal tuberculoma.
PG  - 42
LID - 42
AB  - The use of anti-tubercular therapy (ATT) along with anti-retroviral therapy (ART) 
      in human immunodeficiency virus-tuberculosis (HIV-TB) co-infected individuals 
      could at times lead to paradoxical worsening due to an increase in the 
      inflammatory activity due to immune reconstitution inflammatory syndrome (IRIS) 
      in the eye. This is characterized by anterior and posterior segment inflammatory 
      reactions which may occur in the form of serous retinal detachment. We describe a 
      case where the use of intravitreal anti-vascular endothelial growth factor 
      (anti-VEGF) agent led to resolution of the serous retinal detachment, which had 
      failed to respond to other common modalities of treatment.An HIV-TB co-infected 
      18-year-old, male patient, who was started on ART and ATT developed IRIS in the 
      form of worsening of serous retinal detachment around a pre-existent asymptomatic 
      tuberculoma. The patient was initially treated with oral and topical steroids 
      without a satisfactory response. Intravitreal bevacizumab was then tried for this 
      patient. Serial fundus photos and optical coherence tomography (OCT) taken before 
      and after treatment showed complete resolution of the serous retinal detachment 
      with two doses of intravitreal bevacizumab.Intravitreal anti-VEGF agents may have 
      a role in the reversal of serous retinal detachment, which occurs as a part of 
      IRIS in HIV-tuberculosis co-infected individuals who have been started on 
      anti-tubercular and anti-retroviral therapies.
FAU - Jain, Sahil
AU  - Jain S
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India.
FAU - Bajgai, Priya
AU  - Bajgai P
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India.
FAU - Tigari, Basavaraj
AU  - Tigari B
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India.
FAU - Sharma, Kusum
AU  - Sharma K
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India.
FAU - Sharma, Aman
AU  - Sharma A
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India.
FAU - Gupta, Vishali
AU  - Gupta V
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India.
FAU - Singh, Ramandeep
AU  - Singh R
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Sector 12, Chandigarh, India. mankoo95@yahoo.com.
LA  - eng
PT  - Letter
DEP - 20161108
PL  - Germany
TA  - J Ophthalmic Inflamm Infect
JT  - Journal of ophthalmic inflammation and infection
JID - 101553216
PMC - PMC5099299
OTO - NOTNLM
OT  - Bevacizumab
OT  - HIV-TB co-infection
OT  - IRIS
OT  - Immune recovery uveitis
OT  - Serous retinal detachment
EDAT- 2016/11/09 06:00
MHDA- 2016/11/09 06:01
PMCR- 2016/11/08
CRDT- 2016/11/09 06:00
PHST- 2016/08/25 00:00 [received]
PHST- 2016/10/28 00:00 [accepted]
PHST- 2016/11/09 06:00 [entrez]
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2016/11/09 06:01 [medline]
PHST- 2016/11/08 00:00 [pmc-release]
AID - 10.1186/s12348-016-0112-1 [pii]
AID - 112 [pii]
AID - 10.1186/s12348-016-0112-1 [doi]
PST - ppublish
SO  - J Ophthalmic Inflamm Infect. 2016 Dec;6(1):42. doi: 10.1186/s12348-016-0112-1. 
      Epub 2016 Nov 8.