PMID- 27825906
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20170917
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 93
IP  - Pt A
DP  - 2016 Dec
TI  - Aberrant intra-salience network dynamic functional connectivity impairs 
      large-scale network interactions in schizophrenia.
PG  - 262-270
LID - S0028-3932(16)30399-2 [pii]
LID - 10.1016/j.neuropsychologia.2016.11.003 [doi]
AB  - Aberrant functional interactions between several large-scale networks, especially 
      the central executive network (CEN), the default mode network (DMN) and the 
      salience network (SN), have been postulated as core pathophysiologic features of 
      schizophrenia; however, the attributing factors of which remain unclear. The 
      study employed resting-state fMRI with 77 participants (42 patients and 35 
      controls). We performed dynamic functional connectivity (DFC) and functional 
      connectivity (FC) analyses to explore the connectivity patterns of these 
      networks. Furthermore, we performed a structural equation model (SEM) analysis to 
      explore the possible role of the SN in modulating network interactions. The 
      results were as follows: (1) The inter-network connectivity showed decreased 
      connectivity strength and increased time-varying instability in schizophrenia; 
      (2) The SN manifested schizophrenic intra-network dysfunctions in both the FC and 
      DFC patterns; (3) The connectivity properties of the SN were effective in 
      discriminating controls from patients; (4) In patients, the dynamic intra-SN 
      connectivity negatively predicted the inter-network FC, and this effect was 
      mediated by intra-SN connectivity strength. These findings suggest that 
      schizophrenia show systematic deficits in temporal stability of large-scale 
      network connectivity. Furthermore, aberrant network interactions in schizophrenia 
      could be attributed to instable intra-SN connectivity and the dysfunction of the 
      SN may be an intrinsic biomarker of the disease.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Wang, Xiangpeng
AU  - Wang X
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing 400715, China.
FAU - Zhang, Wenwen
AU  - Zhang W
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing 400715, China.
FAU - Sun, Yujing
AU  - Sun Y
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing 400715, China.
FAU - Hu, Min
AU  - Hu M
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing 400715, China.
FAU - Chen, Antao
AU  - Chen A
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing 400715, China. Electronic address: 
      xscat@swu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20161105
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Brain/diagnostic imaging/drug effects/*physiopathology
MH  - Brain Mapping
MH  - Discriminant Analysis
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/drug effects/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - Rest
MH  - Schizophrenia/diagnostic imaging/drug therapy/*physiopathology
OTO - NOTNLM
OT  - Central executive network
OT  - Default mode network
OT  - Dynamic functional connectivity
OT  - Salience network
OT  - Schizophrenia
EDAT- 2016/11/09 06:00
MHDA- 2017/05/10 06:00
CRDT- 2016/11/10 06:00
PHST- 2016/03/14 00:00 [received]
PHST- 2016/09/26 00:00 [revised]
PHST- 2016/11/03 00:00 [accepted]
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2016/11/10 06:00 [entrez]
AID - S0028-3932(16)30399-2 [pii]
AID - 10.1016/j.neuropsychologia.2016.11.003 [doi]
PST - ppublish
SO  - Neuropsychologia. 2016 Dec;93(Pt A):262-270. doi: 
      10.1016/j.neuropsychologia.2016.11.003. Epub 2016 Nov 5.