PMID- 27826058
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20181005
IS  - 1600-0641 (Electronic)
IS  - 0168-8278 (Linking)
VI  - 66
IP  - 3
DP  - 2017 Mar
TI  - The progenitor cell dilemma: Cellular and functional heterogeneity in assistance 
      or escalation of liver injury.
PG  - 619-630
LID - S0168-8278(16)30644-4 [pii]
LID - 10.1016/j.jhep.2016.10.033 [doi]
AB  - Liver progenitor cells (LPCs) are quiescent cells that are activated during liver 
      injury and thought to give rise to hepatocytes and cholangiocytes in order to 
      support liver regeneration and tissue restitution. While hepatocytes are capable 
      of self-renewal, during most chronic injuries the proliferative capacity of 
      hepatocytes is inhibited, thus LPCs provide main source for regeneration. Despite 
      extensive lineage tracing studies, their role and involvement in these processes 
      are often controversial. Additionally, increasing evidence suggests that the LPC 
      compartment consists of heterogeneous cell populations that are actively involved 
      in cellular interactions with myeloid and lymphoid cells during regeneration. On 
      the other hand, LPC expansion has been associated with an increased fibrogenic 
      response, raising concerns about the therapeutic use of these cells. This review 
      aims to summarize the current understanding of the identity, the cellular 
      interactions and the key pathways affecting the biology of LPCs. Understanding 
      the regulatory circuits and the specific role of LPCs is especially important as 
      it could provide novel therapeutic platforms for the treatment of liver 
      inflammation, fibrosis and regeneration.
CI  - Copyright (c) 2016 European Association for the Study of the Liver. Published by 
      Elsevier B.V. All rights reserved.
FAU - Lukacs-Kornek, Veronika
AU  - Lukacs-Kornek V
AD  - Department of Medicine II, Saarland University Medical Center, Saarland 
      University, Homburg, Germany. Electronic address: lukacsver@aol.com.
FAU - Lammert, Frank
AU  - Lammert F
AD  - Department of Medicine II, Saarland University Medical Center, Saarland 
      University, Homburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161105
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Cell- and Tissue-Based Therapy
MH  - Hepatocytes/cytology/physiology
MH  - Humans
MH  - Liver/*cytology/*injuries
MH  - Liver Neoplasms/etiology/pathology
MH  - Liver Regeneration/physiology
MH  - Stem Cell Niche/physiology
MH  - Stem Cells/*cytology/physiology
OTO - NOTNLM
OT  - Immune crosstalk
OT  - Inflammation
OT  - Progenitor cells
OT  - Regeneration
EDAT- 2016/11/09 06:00
MHDA- 2018/03/13 06:00
CRDT- 2016/11/10 06:00
PHST- 2016/08/15 00:00 [received]
PHST- 2016/10/18 00:00 [revised]
PHST- 2016/10/31 00:00 [accepted]
PHST- 2016/11/09 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2016/11/10 06:00 [entrez]
AID - S0168-8278(16)30644-4 [pii]
AID - 10.1016/j.jhep.2016.10.033 [doi]
PST - ppublish
SO  - J Hepatol. 2017 Mar;66(3):619-630. doi: 10.1016/j.jhep.2016.10.033. Epub 2016 Nov 
      5.