PMID- 27829385
OWN - NLM
STAT- MEDLINE
DCOM- 20170906
LR  - 20181113
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 16
IP  - 1
DP  - 2016 Nov 9
TI  - Complete response of extramedullary relapse in breast of acute T lymphoblastic 
      leukemia after bone marrow transplantation to chemoradiotherapy: a case report 
      and literature review.
PG  - 875
LID - 875
AB  - BACKGROUND: Relapse of acute lymphoblastic leukemia (ALL) occurring in the breast 
      after allografting is extremely rare, with only 22 reported cases in the 
      literature thus far. Further, the lack of a systemic analysis provides little 
      information about this entity. We present a case of isolated extramedullary 
      relapse from acute T lymphoblastic leukemia (ATLL) after allogeneic hematopoietic 
      stem cell transplantation (HSCT). CASE PRESENTATION: A 32-year-old Chinese woman 
      diagnosed with ATLL with myeloid antigen expression received HSCT from her human 
      leukocyte antigen (HLA)-matched sister and presented with two lesions in her 
      right breast 6 months later. Pathology investigation revealed breast relapse, 
      with complete remission on the basis of bone marrow findings. Combined modality 
      treatment including chemotherapy and local radiotherapy helped achieve complete 
      remission with mild side effects. CONCLUSION: The findings from this case 
      indicate that the breast is a potentially involved extramedullary site of relapse 
      for ALL patients after HSCT. In the case of a newly developed breast lump in such 
      patients, clinicians consider local relapse even if the bone marrow findings 
      indicate remission. Combined modality treatment will contribute to better local 
      control and improve prognosis.
FAU - Liu, Bailong
AU  - Liu B
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 71 Xinmin 
      Street, Changchun, 130021, China.
FAU - Liu, Bin
AU  - Liu B
AD  - Department of Hand Surgery, The First Hospital, Jilin University, 71 Xinmin 
      Street, Changchun, 130021, China.
FAU - Wang, Xu
AU  - Wang X
AD  - Cancer Center, The First Hospital, Jilin University, 71 Xinmin Street, Changchun, 
      130021, China.
FAU - Guo, Liang
AU  - Guo L
AD  - Department of Pathology, The First Hospital, Jilin University, 71 Xinmin Street, 
      Changchun, 130021, China.
FAU - Liu, Xiaoliang
AU  - Liu X
AD  - Cancer Center, The First Hospital, Jilin University, 71 Xinmin Street, Changchun, 
      130021, China.
FAU - Han, Wei
AU  - Han W
AD  - Cancer Center, The First Hospital, Jilin University, 71 Xinmin Street, Changchun, 
      130021, China.
FAU - Dong, Lihua
AU  - Dong L
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 71 Xinmin 
      Street, Changchun, 130021, China. drlhdong@163.com.
FAU - Liu, Min
AU  - Liu M
AD  - Department of Radiation Oncology, The First Hospital, Jilin University, 71 Xinmin 
      Street, Changchun, 130021, China. liumin602822@163.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161109
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Adult
MH  - Bone Marrow Transplantation
MH  - Breast Neoplasms/diagnostic imaging/*therapy
MH  - Chemoradiotherapy/*methods
MH  - Female
MH  - Humans
MH  - Neoplasm Recurrence, Local/diagnostic imaging/*therapy
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*therapy
MH  - Treatment Outcome
PMC - PMC5103363
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia
OT  - Breast
OT  - Case report
OT  - Extramedullary relapse
OT  - Radiotherapy
OT  - Transplantation
EDAT- 2016/11/11 06:00
MHDA- 2017/09/07 06:00
PMCR- 2016/11/09
CRDT- 2016/11/11 06:00
PHST- 2016/05/06 00:00 [received]
PHST- 2016/10/27 00:00 [accepted]
PHST- 2016/11/11 06:00 [entrez]
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2016/11/09 00:00 [pmc-release]
AID - 10.1186/s12885-016-2910-0 [pii]
AID - 2910 [pii]
AID - 10.1186/s12885-016-2910-0 [doi]
PST - epublish
SO  - BMC Cancer. 2016 Nov 9;16(1):875. doi: 10.1186/s12885-016-2910-0.