PMID- 27830017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 8
IP  - 10
DP  - 2016
TI  - CCAT1 promotes laryngeal squamous cell carcinoma cell proliferation and invasion.
PG  - 4338-4345
AB  - Long noncoding RNAs (lncRNAs) are proved tobe deregulated in a number of cancers 
      and play important roles in tumor biology. Colon cancer-associated transcript-1 
      (CCAT1) was initially found in colon cancer and promoted cancer cell development. 
      However, the role of CCAT1 in laryngeal squamous cell carcinoma (LSCC) is still 
      unknown. In this study, we demonstrated that CCAT1 expression was upregulated in 
      the LSCC tissues compared with the normal adjacent tissues. Moreover, CCAT1 
      expression was higher in LSCC tissues thanin adjacent normal tissues in 70% of 
      patients. In addition, higher expression of CCAT1 was correlated with T3-4 grade 
      and advanced clinical stage. Overexpression of CCAT1 promoted Hep-2 cell 
      proliferation, migration and invasion. Ectopic expression of CCAT1 suppressed 
      E-cadherin expression while enhanced the expressionof N-cadherin and Vimentin. 
      Furthermore, CCAT1 overexpression increased Hep-2 cell colony formation and cell 
      cycle. We also demonstrated that CCAT1 overexpression suppressed the expression 
      of let-7 and enhanced the expression of HMGA2 and Myc, the direct target genes of 
      let-7. To conclude, our data demonstrated that CCAT1 played an oncogenic role in 
      the development of LSCC.
FAU - Zhuang, Kun
AU  - Zhuang K
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University 23 Youzheng Street, Harbin, Heilongjiang Province 
      150001, China.
FAU - Wu, Qiang
AU  - Wu Q
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University 23 Youzheng Street, Harbin, Heilongjiang Province 
      150001, China.
FAU - Jiang, Senhe
AU  - Jiang S
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University 23 Youzheng Street, Harbin, Heilongjiang Province 
      150001, China.
FAU - Yuan, Huijun
AU  - Yuan H
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University 23 Youzheng Street, Harbin, Heilongjiang Province 
      150001, China.
FAU - Huang, Shaomin
AU  - Huang S
AD  - Department of Otolaryngology Head and Neck Surgery, The Forest Industry General 
      Hospital 32 Hexing Road, Harbin, Heilongjiang Province 150080, China.
FAU - Li, Huijun
AU  - Li H
AD  - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Harbin Medical University 23 Youzheng Street, Harbin, Heilongjiang Province 
      150001, China.
LA  - eng
PT  - Journal Article
DEP - 20161015
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC5095326
OTO - NOTNLM
OT  - CCAT1
OT  - Long noncoding RNAs
OT  - laryngeal squamous cell carcinoma
OT  - lncRNAs
EDAT- 2016/11/11 06:00
MHDA- 2016/11/11 06:01
PMCR- 2016/10/15
CRDT- 2016/11/11 06:00
PHST- 2016/02/09 00:00 [received]
PHST- 2016/05/31 00:00 [accepted]
PHST- 2016/11/11 06:00 [entrez]
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2016/11/11 06:01 [medline]
PHST- 2016/10/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2016 Oct 15;8(10):4338-4345. eCollection 2016.