PMID- 27830498
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2194-7791 (Print)
IS  - 2194-7791 (Electronic)
IS  - 2194-7791 (Linking)
VI  - 3
IP  - 1
DP  - 2016 Dec
TI  - Wilms' tumor susceptibility: possible involvement of FOXP3 and CXCL12 genes.
PG  - 36
LID - 36
AB  - BACKGROUND: Wilms' tumor is an embryonal neoplasm of the kidney that accounts for 
      approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine 
      ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor type 4) are involved in 
      the development of several organs, including the kidney, and are also associated 
      with tumor growth and metastasis. FOXP3 (forkhead transcription factor 3) was 
      initially described as a marker for regulatory T cells; however, its expression 
      in several types of tumor cells has already been described and may have 
      prognostic significance. The aim of the present study was to analyze rs3761548 
      and rs2232365 FOXP3 polymorphisms, as well as evaluate rs1801157 CXCL12 
      polymorphism in Wilms' tumor samples. METHODS: Polymorphisms were evaluated in 32 
      patients and 78 neoplasia-free controls. Genotypes of rs1801157 were determined 
      using PCR-restriction fragment length polymorphism (PCR-RFLP) method, and 
      genotypes of rs2232365 and rs3761548 were determined using allele-specific PCR 
      (AS-PCR). RESULTS: The case-control study indicated a significant association for 
      allele A carriers of rs1801157 polymorphism in relation to Wilms' tumor 
      susceptibility (OR = 5.261; 95 % CI 2.156 to 12.84; p = 0.0002). The opposite was 
      observed in male carriers of G allele for rs2232365 polymorphism (OR 0.1164; 95 % 
      CI 0.0227 to 0.5954; p = 0.0091) or when male and female subjects were analyzed 
      (OR = 0.1304; 95 % CI 0.05013 to 0.3394; p < 0.0001). CONCLUSIONS: All in all, 
      these markers may contribute to this neoplasia susceptibility and progression; 
      however, further studies are needed to real clarify their role in Wilms' tumor 
      pathogenesis.
FAU - Ozawa, Patricia Midori Murobushi
AU  - Ozawa PM
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil.
FAU - Ariza, Carolina Batista
AU  - Ariza CB
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil.
FAU - Losi-Guembarovski, Roberta
AU  - Losi-Guembarovski R
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil.
FAU - Guembarovski, Alda Losi
AU  - Guembarovski AL
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, State University of Londrina, Londrina, PR, Brazil.
FAU - de Oliveira, Carlos Eduardo Coral
AU  - de Oliveira CE
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil.
FAU - Banin-Hirata, Bruna Karina
AU  - Banin-Hirata BK
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil.
FAU - Kishima, Marina Okuyama
AU  - Kishima MO
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, State University of Londrina, Londrina, PR, Brazil.
FAU - Petenuci, Diego Lima
AU  - Petenuci DL
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil.
FAU - Watanabe, Maria Angelica Ehara
AU  - Watanabe MA
AD  - Department of Pathological Sciences, Laboratory of Study and Application of DNA 
      Polymorphisms, Biological Sciences Center, State University of Londrina, 
      Londrina, PR, Brazil. maewatuel@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20161110
PL  - Germany
TA  - Mol Cell Pediatr
JT  - Molecular and cellular pediatrics
JID - 101660689
PMC - PMC5103003
OTO - NOTNLM
OT  - CXCL12
OT  - FOXP3
OT  - Genetic polymorphism
OT  - Wilms' tumor
EDAT- 2016/11/11 06:00
MHDA- 2016/11/11 06:01
PMCR- 2016/11/10
CRDT- 2016/11/11 06:00
PHST- 2016/08/08 00:00 [received]
PHST- 2016/10/18 00:00 [accepted]
PHST- 2016/11/11 06:00 [entrez]
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2016/11/11 06:01 [medline]
PHST- 2016/11/10 00:00 [pmc-release]
AID - 10.1186/s40348-016-0064-4 [pii]
AID - 64 [pii]
AID - 10.1186/s40348-016-0064-4 [doi]
PST - ppublish
SO  - Mol Cell Pediatr. 2016 Dec;3(1):36. doi: 10.1186/s40348-016-0064-4. Epub 2016 Nov 
      10.