PMID- 27830888
OWN - NLM
STAT- MEDLINE
DCOM- 20190704
LR  - 20190704
IS  - 0015-5659 (Print)
IS  - 0015-5659 (Linking)
VI  - 76
IP  - 1
DP  - 2017
TI  - Morphometric evaluation of the delayed cerebral arteries response to 
      acetazolamide test in patients with chronic carotid artery stenosis using 
      computed tomography angiography.
PG  - 10-14
LID - 10.5603/FM.a2016.0034 [doi]
AB  - BACKGROUND: The evidence accumulates that the response to acetazolamide test is 
      delayed on the ipsilateral side to stenosis. However, the effect of acetazolamide 
      beyond 30 min after acetazolamide administration remains unknown. The aim of this 
      study was to assess the diameters of anterior cerebral arteries (ACAs), middle 
      cerebral arteries (MCAs) and posterior cerebral arteries (PCAs) before and 60 min 
      after the acetazolamide test. MATERIALS AND METHODS: Seventeen patients with 
      carotid artery stenosis >/= 90% on the ipsilateral side and </= 50% on the 
      contralateral side were enrolled into the study. Diagnosis was based on 
      ultrasonography examination and was confirmed using digital subtractive 
      angiography. In all patients, two computed tomography angiography examinations 
      were carried out; the first was performed before the acetazolamide 
      administration, while the second one was carried out 60 min after injections. 
      RESULTS: In response to the acetazolamide test: PCA diameter diminished in both 
      ipsi- and contra-lateral side to stenosis (from 1.31 to 1.24 mm and from 1.23 to 
      1.15 mm, respectively), ACA and MCA decreased in the contralateral side to the 
      stenosis (from 1.33 to 1.26 mm and from 2.75 to 2.66 mm, respectively), ACA and 
      MCA increased in the ipsilateral side to the stenosis (from 1.29 to 1.46 mm and 
      from 2.77 to 2.96 mm, respectively). All changes were statistically significant. 
      CONCLUSIONS: There were significant differences in reactivity to acetazolamide 
      challenge between the internal carotid artery (ICA) and vertebrobasilar 
      circulation in patients suffering from chronic carotid artery stenosis. Within 
      the ICA territory, ACA and MCA responses vary in the affected and not affected 
      side.
FAU - Szarmach, A
AU  - Szarmach A
FAU - Winklewski, P J
AU  - Winklewski PJ
AD  - Medical University of Gdansk. pawelwinklewski@wp.pl.
FAU - Halena, G
AU  - Halena G
FAU - Kaszubowski, M
AU  - Kaszubowski M
FAU - Dzierzanowski, J
AU  - Dzierzanowski J
FAU - Piskunowicz, M
AU  - Piskunowicz M
FAU - Szurowska, E
AU  - Szurowska E
FAU - Frydrychowski, A F
AU  - Frydrychowski AF
LA  - eng
PT  - Journal Article
DEP - 20161110
PL  - Poland
TA  - Folia Morphol (Warsz)
JT  - Folia morphologica
JID - 0374620
RN  - O3FX965V0I (Acetazolamide)
SB  - IM
MH  - Acetazolamide/*administration & dosage
MH  - Adult
MH  - Aged
MH  - *Carotid Artery, Internal/diagnostic imaging/physiopathology
MH  - Carotid Stenosis/diagnostic imaging/physiopathology
MH  - *Cerebral Arteries/diagnostic imaging/physiopathology
MH  - *Computed Tomography Angiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - acetazolamide test
OT  - cerebral arteries
OT  - cerebral regional reactivity
OT  - computed tomography angiography
EDAT- 2016/11/11 06:00
MHDA- 2019/07/05 06:00
CRDT- 2016/11/11 06:00
PHST- 2016/03/11 00:00 [received]
PHST- 2016/05/28 00:00 [accepted]
PHST- 2016/05/25 00:00 [revised]
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2019/07/05 06:00 [medline]
PHST- 2016/11/11 06:00 [entrez]
AID - VM/OJS/J/45104 [pii]
AID - 10.5603/FM.a2016.0034 [doi]
PST - ppublish
SO  - Folia Morphol (Warsz). 2017;76(1):10-14. doi: 10.5603/FM.a2016.0034. Epub 2016 
      Nov 10.